TC 1698 dihydrochloride

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Cat.No. 2518 - TC 1698 dihydrochloride | C13H18N2.2HCl | CAS No. 787587-06-8
Description: α7-selective agonist
Chemical Name: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.

Technical Data

M. Wt 275.22
Formula C13H18N2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 787587-06-8
PubChem ID 21094258
InChI Key ZQUQBCHNSBJMCG-UHFFFAOYSA-N
Smiles C1(C2N3CCC(CC3)CC2)=CC=CN=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 27.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 275.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.17 mL 36.33 mL
5 mM 0.73 mL 3.63 mL 7.27 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16 PMID: 14722323

Papke et al (2005) Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11 PMID: 16266703


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Keywords: TC 1698 dihydrochloride, supplier, α7, alpha7-selective, agonists, α7Nicotinic, a7Nicotinic, Receptors, Acetylcholine, nAChR, TC1698, dihydrochloride, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience

Citations for TC 1698 dihydrochloride

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