TC 14012

Pricing Availability Delivery Time Qty
Cat.No. 4300 - TC 14012 | Arg-Arg-Nal-Cys-Tyr-Cit-Lys-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (Modifications: Disulfide bridge between 4 - 13, Cit-8 = D-Citrulline) | CAS No. 368874-34-4
Description: CXCR4 antagonist; ACKR3 (CXCR7) agonist
Datasheet
Citations
Literature

Biological Activity

CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).

Technical Data

M. Wt 2066.43
Formula C90H140N34O19S2
Sequence RRACYXKXPYRXCR

(Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline)

Storage Store at -20°C
CAS Number 368874-34-4
PubChem ID 90488928
InChI Key SGDDHDBBOJNZKY-UXNLHULBSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2066.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.48 mL 2.42 mL 4.84 mL
5 mM 0.1 mL 0.48 mL 0.97 mL
10 mM 0.05 mL 0.24 mL 0.48 mL
50 mM 0.01 mL 0.05 mL 0.1 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656 PMID: 14649896

Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824 PMID: 15905192

Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939 PMID: 20956518


If you know of a relevant reference for TC 14012, please let us know.

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Keywords: TC14012 cxcr4 antagonists inverse agonists cxcr7 chemokines Chemokine CXC Receptors

Citations for TC 14012

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Literature in this Area

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Pathways for TC 14012

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