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Submit ReviewtBPC
Discontinued Product
tBPC (Cat. No. 6411) has been withdrawn from sale for commercial reasons.
Description: Positive allosteric modulator of NPY Y4 receptor
Chemical Name: 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
Purity: ≥98% (HPLC)
Biological Activity for tBPC
tBPC is a positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R.
Technical Data for tBPC
| M. Wt | 248.36 |
| Formula | C16H24O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1942-71-8 |
| PubChem ID | 16033 |
| InChI Key | FTIXUILRMBSXNS-UHFFFAOYSA-N |
| Smiles | CC(C)(C1=CC=C(C=C1)OC2CCCCC2O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for tBPC
References for tBPC
References are publications that support the biological activity of the product.
Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID: 28795803
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Keywords: tBPC, tBPC supplier, Neuropeptide, Y, receptor, 4, NPY, Y4R, positive, allosteric, modulators, modulates, PAM, Receptors, 6411, Tocris Bioscience
Citations for tBPC
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Currently there are no citations for tBPC.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.