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Biological Activity for tBPC
tBPC is a positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R.
Compound Libraries for tBPC
Technical Data for tBPC
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for tBPC
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for tBPC
The following data is based on the product molecular weight 248.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.03 mL||20.13 mL||40.26 mL|
|5 mM||0.81 mL||4.03 mL||8.05 mL|
|10 mM||0.4 mL||2.01 mL||4.03 mL|
|50 mM||0.08 mL||0.4 mL||0.81 mL|
References for tBPC
References are publications that support the biological activity of the product.
Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID: 28795803
If you know of a relevant reference for tBPC, please let us know.
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Keywords: tBPC, tBPC supplier, Neuropeptide, Y, receptor, 4, NPY, Y4R, positive, allosteric, modulators, modulates, PAM, Receptors, 6411, Tocris Bioscience
Citations for tBPC
Citations are publications that use Tocris products.
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Reviews for tBPC
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.