Pricing Availability   Qty
Description: Positive allosteric modulator of NPY Y4 receptor
Chemical Name: 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for tBPC

tBPC is a positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R.

Compound Libraries for tBPC

tBPC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for tBPC

M. Wt 248.36
Formula C16H24O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1942-71-8
PubChem ID 16033
Smiles CC(C)(C1=CC=C(C=C1)OC2CCCCC2O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for tBPC

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.84 100
ethanol 24.84 100

Preparing Stock Solutions for tBPC

The following data is based on the product molecular weight 248.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.13 mL 40.26 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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References for tBPC

References are publications that support the biological activity of the product.

Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID: 28795803

If you know of a relevant reference for tBPC, please let us know.

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Keywords: tBPC, tBPC supplier, Neuropeptide, Y, receptor, 4, NPY, Y4R, positive, allosteric, modulators, modulates, PAM, Receptors, 6411, Tocris Bioscience

Citations for tBPC

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