tBPC

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Cat.No. 6411 - tBPC | C16H24O2 | CAS No. 1942-71-8
Description: Positive allosteric modulator of NPY Y4 receptor
Chemical Name: 2-[4-(1,1-Dimethylethyl)phenoxy]cyclohexanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Positive allosteric modulator of neuropeptide Y receptor 4 (Y4R). Potentiates Y4R response to pancreatic polypeptide (PP), neuropeptide Y (NPY) and peptide YY (PYY) (EC50 values are 0.03, 0.4 and 0.5 nM respectively). Shows selectivity for Y4R over Y1R, Y2R and Y5R.

Technical Data

M. Wt 248.36
Formula C16H24O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1942-71-8
PubChem ID 16033
InChI Key FTIXUILRMBSXNS-UHFFFAOYSA-N
Smiles CC(C)(C1=CC=C(C=C1)OC2CCCCC2O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.84 100
ethanol 24.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.13 mL 40.26 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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References

References are publications that support the biological activity of the product.

Schubert et al (2017) Identification and characterization of the first selective Y4 receptor positive allosteric modulator. J.Med.Chem. 60 7605 PMID: 28795803


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Keywords: tBPC, tBPC supplier, Neuropeptide, Y, receptor, 4, NPY, Y4R, positive, allosteric, modulators, modulates, PAM, Receptors, 6411, Tocris Bioscience

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