TAT-Gap19

Pricing Availability Delivery Time Qty
Cat.No. 6227 - TAT-Gap19 | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys | CAS No. 1507930-54-2
Description: Cx43 hemichannel blocker
Datasheet
Citations
Literature

Biological Activity

Cx43 hemichannel blocker (IC50 ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.

Technical Data

M. Wt 2703.28
Formula C119H212N46O26
Sequence YGRKKRRQRRRKQIEIKKFK
Storage Store at -20°C
CAS Number 1507930-54-2
PubChem ID 127021051
InChI Key ALNCFPIRTLVJPY-XELKYWHDNA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2703.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.37 mL 1.85 mL 3.7 mL
5 mM 0.07 mL 0.37 mL 0.74 mL
10 mM 0.04 mL 0.18 mL 0.37 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 8 1 PMID: 25374505

Freitas-Andrade and Naus (2016) Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 323 207 PMID: 25913636


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Keywords: TAT-Gap19, supplier, Inhibitors, Inhibits, connexin43, Cx43, Brain, penetrant, Cell, permeable, Gap, Channels, Gap, Channels, Tocris Bioscience

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