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Cat.No. 5353 - Gap19 | Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys | CAS No. 1507930-57-5
Description: Cx43 hemichannel blocker

Biological Activity

Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Technical Data

M. Wt 1161.45
Formula C55H96N14O13
Storage Store at -20°C
CAS Number 1507930-57-5
PubChem ID 91691126
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1161.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.86 mL 4.3 mL 8.61 mL
5 mM 0.17 mL 0.86 mL 1.72 mL
10 mM 0.09 mL 0.43 mL 0.86 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505

If you know of a relevant reference for Gap19, please let us know.

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Keywords: Gap19, supplier, Selective, Cx43, hemichannels, blockers, blocks, Connexin43, Panx-1, gap, junctions, Gap, Channels, Gap, Channels, Tocris Bioscience

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