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Biological Activity for Gap19
Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.
Technical Data for Gap19
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Gap19
|Solubility||Soluble to 2 mg/ml in water|
References for Gap19
References are publications that support the biological activity of the product.
Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924
Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389
Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505
If you know of a relevant reference for Gap19, please let us know.
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Keywords: Gap19, Gap19 supplier, Selective, Cx43, hemichannels, blockers, blocks, Connexin43, Panx-1, gap, junctions, Gap, Channels, 5353, Tocris Bioscience
3 Citations for Gap19
Citations are publications that use Tocris products. Selected citations for Gap19 include:
Almad et al (2016) Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia 64 1154 PMID: 27083773
Best et al (2019) Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. Nat Commun 10 4190 PMID: 31519898
Chen et al (2018) Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci 12 372 PMID: 30386214
Do you know of a great paper that uses Gap19 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.