Gap19

Pricing Availability Delivery Time Qty
Cat.No. 5353 - Gap19 | Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys | CAS No. 1507930-57-5
Description: Cx43 hemichannel blocker
Datasheet
Citations
Literature

Biological Activity

Selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Technical Data

M. Wt 1161.45
Formula C55H96N14O13
Sequence KQIEIKKFK
Storage Store at -20°C
CAS Number 1507930-57-5
PubChem ID 91691126
InChI Key IEAKEKFIXUZWEH-PKMKMBMKSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1161.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.86 mL 4.3 mL 8.61 mL
5 mM 0.17 mL 0.86 mL 1.72 mL
10 mM 0.09 mL 0.43 mL 0.86 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505


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Keywords: Selective Cx43 hemichannels blockers blocks Connexin43 Panx-1 gap junctions Gap Channels

Citations for Gap19

Citations are publications that use Tocris products.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Gap19

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