Gap19

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Cx43 hemichannel blocker
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews

Biological Activity for Gap19

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

Technical Data for Gap19

M. Wt 1161.45
Formula C55H96N14O13
Sequence KQIEIKKFK
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1507930-57-5
PubChem ID 91691126
InChI Key IEAKEKFIXUZWEH-PKMKMBMKSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gap19

Solubility Soluble to 2 mg/ml in water

Product Datasheets for Gap19

Certificate of Analysis / Product Datasheet
Select another batch:

References for Gap19

References are publications that support the biological activity of the product.

Boengler et al (2013) Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 4 PMID: 23760924

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Abudara et al (2014) The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front Cell Neurosci. 8 PMID: 25374505


If you know of a relevant reference for Gap19, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Gap Channel Blockers

Keywords: Gap19, Gap19 supplier, Selective, Cx43, hemichannels, blockers, blocks, Connexin43, Panx-1, gap, junctions, Gap, Channels, 5353, Tocris Bioscience

5 Citations for Gap19

Citations are publications that use Tocris products. Selected citations for Gap19 include:

Almad et al (2016) Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia 64 1154 PMID: 27083773

Juan V et al (2021) Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? Front Pharmacol 12 613449 PMID: 33867979

Chen et al (2018) Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci 12 372 PMID: 30386214

Miyuki et al (2023) The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression. Int J Mol Sci 24 PMID: 36674690


Do you know of a great paper that uses Gap19 from Tocris? Please let us know.

Reviews for Gap19

There are currently no reviews for this product. Be the first to review Gap19 and earn rewards!

Have you used Gap19?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review