Pricing Availability   Qty
Description: Control peptide for TAT-Gap19
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for TAT-Gap19(I130A)

TAT-Gap19(I130A) is a control peptide for TAT-Gap19 (Cat. No. 6227), a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.

Technical Data for TAT-Gap19(I130A)

M. Wt 2661.2
Formula C116H206N46O26
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAT-Gap19(I130A)

Solubility Soluble to 2 mg/ml in water

Product Datasheets for TAT-Gap19(I130A)

References for TAT-Gap19(I130A)

References are publications that support the biological activity of the product.

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Walrave et al (2016) Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. Front.Cell Neurosci. 10 288 PMID: 28066184

If you know of a relevant reference for TAT-Gap19(I130A), please let us know.

View Related Products by Target

View Related Products by Product Action

View all Gap Channel Controls

Keywords: TAT-Gap19(I130A), TAT-Gap19(I130A) supplier, TAT-gap19, control, peptide, Cx43, connexin, hemichannel, Gap, Channels, 7402, Tocris Bioscience

Citations for TAT-Gap19(I130A)

Citations are publications that use Tocris products.

Currently there are no citations for TAT-Gap19(I130A). Do you know of a great paper that uses TAT-Gap19(I130A) from Tocris? Please let us know.

Reviews for TAT-Gap19(I130A)

There are currently no reviews for this product. Be the first to review TAT-Gap19(I130A) and earn rewards!

Have you used TAT-Gap19(I130A)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epilepsy Poster

Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.