TAT-Gap19(I130A)

Pricing Availability   Qty
Description: Control peptide for TAT-Gap19
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TAT-Gap19(I130A)

TAT-Gap19(I130A) is a control peptide for TAT-Gap19 (Cat. No. 6227), a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expression Cx43, TAT-GAP19(1130A) does not inhibit [Ca2+]i-triggered ATP release at 200 μM. TAT-Gap19(I130A) is cell permeable.

Technical Data for TAT-Gap19(I130A)

M. Wt 2661.2
Formula C116H206N46O26
Sequence YGRKKRRQRRRKQAEIKKFK
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key JIFBPYPLZXITDC-KYILVESISA-N
Smiles O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAT-Gap19(I130A)

Solubility Soluble to 2 mg/ml in water

Product Datasheets for TAT-Gap19(I130A)

Certificate of Analysis / Product Datasheet
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References for TAT-Gap19(I130A)

References are publications that support the biological activity of the product.

Wang et al (2013) Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res.Cardiol. 108 309 PMID: 23184389

Walrave et al (2016) Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory. Front.Cell Neurosci. 10 288 PMID: 28066184


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Keywords: TAT-Gap19(I130A), TAT-Gap19(I130A) supplier, TAT-gap19, control, peptide, Cx43, connexin, hemichannel, Gap, Channels, 7402, Tocris Bioscience

Citations for TAT-Gap19(I130A)

Citations are publications that use Tocris products.

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