TAT-cyclo-CLLFVY

Pricing Availability Delivery Time Qty
Cat.No. 5582 - TAT-cyclo-CLLFVY | cyclo(Cys-Leu-Leu-Phe-Val-Tyr) Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln | CAS No. 1446322-66-2
Description: Selective HIF-1 dimerization inhibitor
Datasheet
Citations
Literature

Biological Activity

Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Technical Data

M. Wt 2559.1
Formula C111H188N42O24S2
Sequence CLLFVY CGRKKRRQRRRPPQ*

(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)

Storage Store at -20°C
CAS Number 1446322-66-2
PubChem ID 72192490
InChI Key AWUUHEHYNQGEFC-XLZVTALKSA-N
Smiles [H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2559.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.39 mL 1.95 mL 3.91 mL
5 mM 0.08 mL 0.39 mL 0.78 mL
10 mM 0.04 mL 0.2 mL 0.39 mL
50 mM 0.01 mL 0.04 mL 0.08 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID: 23796364


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View Related Products by Product Action

View all Hypoxia Inducible Factor Inhibitors

Keywords: TAT-cyclo-CLLFVY, supplier, HIF-1a, 1b, 1beta, 1alpha, α, β, hypoxia, inducible, factor, cancer, angiogenesis, antiangiogenic, dimerization, inhibitors, inhibits, HIF, Hypoxia, Inducible, Factors, HIF, Tocris Bioscience

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