TAT-cyclo-CLLFVY

Pricing Availability   Qty
Description: Selective HIF-1 dimerization inhibitor
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.

Technical Data for TAT-cyclo-CLLFVY

M. Wt 2559.1
Formula C111H188N42O24S2
Sequence CLLFVY CGRKKRRQRRRPPQ*

(Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1446322-66-2
PubChem ID 72192490
InChI Key AWUUHEHYNQGEFC-XLZVTALKSA-N
Smiles [H]N[C@@H](CSSC[C@@H]1N([H])C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC1=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAT-cyclo-CLLFVY

Solubility Soluble to 1 mg/ml in water

Product Datasheets for TAT-cyclo-CLLFVY

Certificate of Analysis / Product Datasheet
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References for TAT-cyclo-CLLFVY

References are publications that support the biological activity of the product.

Miranda et al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418 PMID: 23796364


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View Related Products by Product Action

View all Hypoxia Inducible Factor (HIF) Inhibitors

Keywords: TAT-cyclo-CLLFVY, TAT-cyclo-CLLFVY supplier, HIF-1a, 1b, 1beta, 1alpha, α, β, hypoxia, inducible, factor, cancer, angiogenesis, antiangiogenic, dimerization, inhibitors, inhibits, Hypoxia, Inducible, Factors, 5582, Tocris Bioscience

1 Citation for TAT-cyclo-CLLFVY

Citations are publications that use Tocris products. Selected citations for TAT-cyclo-CLLFVY include:

Ying et al (2022) CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy 18 726-744 PMID: 34282994


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Literature in this Area

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