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Submit ReviewTamoxifen
Description: Estrogen receptor partial agonist/antagonist
Chemical Name: 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
Purity: ≥99% (HPLC)
Biological Activity for Tamoxifen
Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.
Compound Libraries for Tamoxifen
Tamoxifen is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Tamoxifen
| M. Wt | 371.51 |
| Formula | C26H29NO |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 10540-29-1 |
| PubChem ID | 2733526 |
| InChI Key | NKANXQFJJICGDU-QPLCGJKRSA-N |
| Smiles | CN(C)CCOC1=CC=C(C=C1)/C(C2=CC=CC=C2)=C(CC)\C3=CC=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tamoxifen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 37.15 | 100 | |
| DMSO | 7.43 | 20 |
Preparing Stock Solutions for Tamoxifen
The following data is based on the product molecular weight 371.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.46 mL | 26.92 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Tamoxifen
References for Tamoxifen
References are publications that support the biological activity of the product.
Jordan et al (2003) Tamoxifen: a most unlikely pioneering medicine. Nat.Rev.Drug Discov. 2 203 PMID: 12612646
If you know of a relevant reference for Tamoxifen, please let us know.
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Keywords: Tamoxifen, Tamoxifen supplier, SERM, selective, estrogen, receptor, modulators, antagonists, antagonism, partial, agonists, agonism, anticancer, chemotherapeutic, Estrogen, and, Related, Receptors, 6342, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Tamoxifen and its salts, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
1 Citation for Tamoxifen
Citations are publications that use Tocris products. Selected citations for Tamoxifen include:
Silva et al (2019) Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment. Biomolecules 9 PMID: 31434290
Do you know of a great paper that uses Tamoxifen from Tocris? Please let us know.
Reviews for Tamoxifen
Average Rating: 5 (Based on 1 Review.)
Have you used Tamoxifen?
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Tamoxifen for ERT-cre mice.
By
Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse
given for tamoxifen-inducible cre mice. saw excellent GFP expression with 2 doses.
given 180mg/kg/day i.p., injections 24 hours apart. dissolved 30mg/ml in 1:9 etoh and sunflower seed oil
Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Nuclear Receptors Product Listing
A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
- Retinoic Acid Receptors
- Retinoid X Receptors
- Vitamin D Receptors
Pathways for Tamoxifen
