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Tamoxifen

Cat. No. 6342 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Cat.No. 6342 - Tamoxifen | C26H29NO | CAS No. 10540-29-1
Description: Estrogen receptor partial agonist/antagonist
Chemical Name: 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

Compound Libraries

Tamoxifen is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.51
Formula C26H29NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 10540-29-1
PubChem ID 2733526
InChI Key NKANXQFJJICGDU-QPLCGJKRSA-N
Smiles CN(C)CCOC1=CC=C(C=C1)/C(C2=CC=CC=C2)=C(CC)\C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 37.15 100
DMSO 7.43 20

Preparing Stock Solutions

The following data is based on the product molecular weight 371.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Jordan et al (2003) Tamoxifen: a most unlikely pioneering medicine. Nat.Rev.Drug Discov. 2 203 PMID: 12612646

If you know of a relevant reference for Tamoxifen, please let us know.

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Keywords: Tamoxifen, Tamoxifen supplier, SERM, selective, estrogen, receptor, modulators, antagonists, antagonism, partial, agonists, agonism, anticancer, chemotherapeutic, Estrogen, and, Related, Receptors, 6342, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Tamoxifen and its salts, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

1 Citation for Tamoxifen

Citations are publications that use Tocris products. Selected citations for Tamoxifen include:

Silva et al (2019) Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment. Biomolecules 9 PMID: 31434290

Do you know of a great paper that uses Tamoxifen from Tocris? Please let us know.

Reviews for Tamoxifen

Average Rating: 5 (Based on 1 Review.)

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Tamoxifen for ERT-cre mice.
By Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse

given for tamoxifen-inducible cre mice. saw excellent GFP expression with 2 doses.

given 180mg/kg/day i.p., injections 24 hours apart. dissolved 30mg/ml in 1:9 etoh and sunflower seed oil

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Literature in this Area

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Nuclear Receptors Product Listing

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Pathways for Tamoxifen

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.