Home / Pharmacology / Nuclear Receptors / Estrogen and Related Receptors / Estrogen and Related Receptor Modulators / Tamoxifen

Tamoxifen

Cat. No. 6342 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 6342 - Tamoxifen | C26H29NO | CAS No. 10540-29-1
Description: Estrogen receptor partial agonist/antagonist
Chemical Name: 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Tamoxifen

Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

Compound Libraries for Tamoxifen

Tamoxifen is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tamoxifen

M. Wt 371.51
Formula C26H29NO
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 10540-29-1
PubChem ID 2733526
InChI Key NKANXQFJJICGDU-QPLCGJKRSA-N
Smiles CN(C)CCOC1=CC=C(C=C1)/C(C2=CC=CC=C2)=C(CC)\C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tamoxifen

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 37.15 100
DMSO 7.43 20

Preparing Stock Solutions for Tamoxifen

The following data is based on the product molecular weight 371.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Tamoxifen

References are publications that support the biological activity of the product.

Jordan et al (2003) Tamoxifen: a most unlikely pioneering medicine. Nat.Rev.Drug Discov. 2 203 PMID: 12612646

If you know of a relevant reference for Tamoxifen, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Modulators

Keywords: Tamoxifen, Tamoxifen supplier, SERM, selective, estrogen, receptor, modulators, antagonists, antagonism, partial, agonists, agonism, anticancer, chemotherapeutic, Estrogen, and, Related, Receptors, 6342, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Tamoxifen and its salts, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

1 Citation for Tamoxifen

Citations are publications that use Tocris products. Selected citations for Tamoxifen include:

Silva et al (2019) Study of the Combination of Self-Activating Photodynamic Therapy and Chemotherapy for Cancer Treatment. Biomolecules 9 PMID: 31434290

Do you know of a great paper that uses Tamoxifen from Tocris? Please let us know.

Reviews for Tamoxifen

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Tamoxifen?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Tamoxifen for ERT-cre mice.
By Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse

given for tamoxifen-inducible cre mice. saw excellent GFP expression with 2 doses.

given 180mg/kg/day i.p., injections 24 hours apart. dissolved 30mg/ml in 1:9 etoh and sunflower seed oil

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for Tamoxifen

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.