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Tamoxifen

Cat. No. 6342 8 Citations 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Estrogen receptor partial agonist/antagonist
Chemical Name: 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (1)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Tamoxifen

Tamoxifen is a selective estrogen receptor modulator (SERM). Exhibits antiestrogenic effects in mammary tissue and estrogen-like effects in bone. Anticancer. Tamoxifen citrate (Cat.No. 0999) is also available.

Compound Libraries for Tamoxifen

Tamoxifen is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Tamoxifen

M. Wt 371.51
Formula C26H29NO
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 10540-29-1
PubChem ID 2733526
InChI Key NKANXQFJJICGDU-QPLCGJKRSA-N
Smiles CN(C)CCOC1=CC=C(C=C1)/C(C2=CC=CC=C2)=C(CC)\C3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tamoxifen

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 37.15 100
DMSO 7.43 20

Preparing Stock Solutions for Tamoxifen

The following data is based on the product molecular weight 371.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for Tamoxifen

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Tamoxifen

References are publications that support the biological activity of the product.

Jordan et al (2003) Tamoxifen: a most unlikely pioneering medicine. Nat.Rev.Drug Discov. 2 203 PMID: 12612646

If you know of a relevant reference for Tamoxifen, please let us know.

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Keywords: Tamoxifen, Tamoxifen supplier, SERM, selective, estrogen, receptor, modulators, antagonists, antagonism, partial, agonists, agonism, anticancer, chemotherapeutic, Estrogen, and, Related, Receptors, 6342, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Tamoxifen and its salts, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

8 Citations for Tamoxifen

Citations are publications that use Tocris products. Selected citations for Tamoxifen include:

Ya-Jing et al (2023) Metabotropic glutamate receptor 5-mediated inhibition of inward-rectifying K+ channel 4.1 contributes to orofacial ectopic mechanical allodynia following inferior alveolar nerve transection in male mice. J Neurosci Res 101 1170-1187 PMID: 36807930

Laurie et al (2020) A homogeneous bioluminescent immunoassay to probe cellular signaling pathway regulation. Commun Biol 3 8 PMID: 31909200

Susana et al (2020) Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer. Cancer Cell 38 516-533.e9 PMID: 32976773

Rachael et al (2020) ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat Genet 52 187-197 PMID: 31913353

Do you know of a great paper that uses Tamoxifen from Tocris? Please let us know.

Reviews for Tamoxifen

Average Rating: 5 (Based on 1 Review.)

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Tamoxifen for ERT-cre mice.
By Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse

given for tamoxifen-inducible cre mice. saw excellent GFP expression with 2 doses.

given 180mg/kg/day i.p., injections 24 hours apart. dissolved 30mg/ml in 1:9 etoh and sunflower seed oil

review image

Pathways for Tamoxifen

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.