Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 405.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.93 mL||24.67 mL||49.33 mL|
|2.5 mM||0.99 mL||4.93 mL||9.87 mL|
|5 mM||0.49 mL||2.47 mL||4.93 mL|
|25 mM||0.1 mL||0.49 mL||0.99 mL|
References are publications that support the biological activity of the product.
Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130 PMID: 2115588
Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601 PMID: 12467901
Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403 PMID: 17220907
If you know of a relevant reference for Taltirelin, please let us know.
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Keywords: Taltirelin, Taltirelin supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, TA, 0910, Thyrotropin-Releasing, Hormone, 2672, Tocris Bioscience
1 Citation for Taltirelin
Citations are publications that use Tocris products. Selected citations for Taltirelin include:
Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120 PMID: 23087672
Do you know of a great paper that uses Taltirelin from Tocris? Please let us know.
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Literature in this Area
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