Taltirelin

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Cat.No. 2672 - Taltirelin | C17H23N7O5 | CAS No. 103300-74-9
Description: Synthetic thyrotropin-releasing hormone analog
Alternative Names: TA 0910
Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
Purity: ≥96% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Technical Data

M. Wt 405.41
Formula C17H23N7O5
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 103300-74-9
PubChem ID 114750
InChI Key LQZAIAZUDWIVPM-SRVKXCTJSA-N
Smiles CN(C(C[C@@H]([C@@](N[C@@H](CC3=CNC=N3)C(N2[C@H]([C@](N)=O)CCC2)=O)=O)N1)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.27 50

Preparing Stock Solutions

The following data is based on the product molecular weight 405.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130 PMID: 2115588

Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601 PMID: 12467901

Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403 PMID: 17220907


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Keywords: Taltirelin, supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, TA, 0910, Thyrotropin-Releasing, Hormone, Receptors, Tocris Bioscience

1 Citation for Taltirelin

Citations are publications that use Tocris products. Selected citations for Taltirelin include:

Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120 PMID: 23087672


Do you know of a great paper that uses Taltirelin from Tocris? If so please let us know.

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Pathways for Taltirelin

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