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Selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 347.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.87 mL||14.37 mL||28.74 mL|
|5 mM||0.57 mL||2.87 mL||5.75 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the biological activity of the product.
McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 31 705 PMID: 15246361
Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1
Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417
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