Talsupram hydrochloride

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Cat.No. 4352 - Talsupram hydrochloride | C20H25NS.HCl | CAS No. 25487-28-9
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Talsupram hydrochloride

Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.

Technical Data for Talsupram hydrochloride

M. Wt 347.95
Formula C20H25NS.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 25487-28-9
PubChem ID 33013
Smiles CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Talsupram hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 6.96 20
DMSO 34.8 100

Preparing Stock Solutions for Talsupram hydrochloride

The following data is based on the product molecular weight 347.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.37 mL 28.74 mL
5 mM 0.57 mL 2.87 mL 5.75 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets for Talsupram hydrochloride

References for Talsupram hydrochloride

References are publications that support the biological activity of the product.

McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 31 705 PMID: 15246361

Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1

Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417

If you know of a relevant reference for Talsupram hydrochloride, please let us know.

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