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Submit ReviewTalsupram hydrochloride
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Talsupram hydrochloride
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.
Technical Data for Talsupram hydrochloride
| M. Wt | 347.95 |
| Formula | C20H25NS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 25487-28-9 |
| PubChem ID | 33013 |
| InChI Key | YMZCMCDSCRSIBS-UHFFFAOYSA-N |
| Smiles | CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Talsupram hydrochloride
References for Talsupram hydrochloride
References are publications that support the biological activity of the product.
McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 31 705 PMID: 15246361
Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1
Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417
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