Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTalsupram hydrochloride
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Talsupram hydrochloride
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.
Technical Data for Talsupram hydrochloride
| M. Wt | 347.95 |
| Formula | C20H25NS.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 25487-28-9 |
| PubChem ID | 33013 |
| InChI Key | YMZCMCDSCRSIBS-UHFFFAOYSA-N |
| Smiles | CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Talsupram hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.96 | 20 | |
| DMSO | 34.8 | 100 |
Preparing Stock Solutions for Talsupram hydrochloride
The following data is based on the product molecular weight 347.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.37 mL | 28.74 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.75 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Talsupram hydrochloride
References for Talsupram hydrochloride
References are publications that support the biological activity of the product.
McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the NE transporter. Nucl.Med.Biol. 31 705 PMID: 15246361
Schou et al (2006) Synthesis and positron emission tomography evaluation of three NE transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1
Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417
If you know of a relevant reference for Talsupram hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Talsupram hydrochloride, Talsupram hydrochloride supplier, norepinephrine, reuptake, inhibitors, inhibits, noradrenaline, noradrenalin, transporters, NET, antidepressants, selective, Adrenergic, Transporters, 4352, Tocris Bioscience
Citations for Talsupram hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Talsupram hydrochloride. Do you know of a great paper that uses Talsupram hydrochloride from Tocris? Please let us know.
Reviews for Talsupram hydrochloride
There are currently no reviews for this product. Be the first to review Talsupram hydrochloride and earn rewards!
Have you used Talsupram hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure