Talsupram hydrochloride

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Cat.No. 4352 - Talsupram hydrochloride | C20H25NS.HCl | CAS No. 25487-28-9
Description: Selective inhibitor of noradrenalin transporters
Chemical Name: 1,3-Dihydro-N,3,3-trimethyl-1-phenylbenzo[c]thiophene-1-propanamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective noradrenalin re-uptake inhibitor; exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Antidepressant.

Technical Data

M. Wt 347.95
Formula C20H25NS.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 25487-28-9
PubChem ID 33013
InChI Key YMZCMCDSCRSIBS-UHFFFAOYSA-N
Smiles CC2(C)SC(C3=CC=CC=C3)(CCCNC)C1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.8 100
water 6.96 20

Preparing Stock Solutions

The following data is based on the product molecular weight 347.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.37 mL 28.74 mL
5 mM 0.57 mL 2.87 mL 5.75 mL
10 mM 0.29 mL 1.44 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McConathy et al (2004) Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter. Nucl.Med.Biol. 31 705 PMID: 15246361

Schou et al (2006) Synthesis and positron emission tomography evaluation of three norepinephrine transporter radioligands: [C-11]desipramine, [C-11]talopram and [C-11]talsupram. Mol.Imaging Biol. 8 1 PMID:

Rowlett et al (2004) Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors. J.Pharmacol.Exp.Ther. 310 342 PMID: 14985417


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