TAK 375

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Description: Very high affinity and selective melatonin receptor agonist
Alternative Names: Ramelteon
Chemical Name: N-[2-[(8S)-1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl]propanamide
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for TAK 375

TAK 375 is a very high affinity and selective melatonin agonist (Ki values are 14 and 112 pM for human MT1 and MT2, respectively). Selective for human MT1 and MT2 over hamster MT3 and a range of other targets including benzodiazepine, opiate and dopamine receptors, ion channels and transporters. Accelerates return to normal circadian rhythm in rats after phase shift, without affecting learning and memory. Also reduces infarct size in rat heart in vitro post ischemia-reperfusion.

Compound Libraries for TAK 375

TAK 375 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TAK 375

M. Wt 259.34
Formula C16H21NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 196597-26-9
PubChem ID 208902
Smiles CCC(NCC[C@@H]1CCC2=C1C3=C(C=C2)OCC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TAK 375

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.93 100
ethanol 25.93 100

Preparing Stock Solutions for TAK 375

The following data is based on the product molecular weight 259.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.28 mL 38.56 mL
5 mM 0.77 mL 3.86 mL 7.71 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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References for TAK 375

References are publications that support the biological activity of the product.

Stroethoff et al (2018) Melatonin receptor agonist rame. reduces ischemia-reperfusion injury through activation of mitochondrial potassium channels. J.Cardiovasc.Pharmacol. 72 106 PMID: 29787401

Hirai et al (2005) Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats J.Biol.Rhythms. 20 27 PMID: 15654068

Kato et al (2005) Neurochemical properties of rame. (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 48 301 PMID: 15695169

If you know of a relevant reference for TAK 375, please let us know.

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Keywords: TAK 375, TAK 375 supplier, TAK375, melatonin, receptor, agonists, agonism, selective, very, high, affinity, MT1, MT2, circadian, rhythm, Ramelteon, Melatonin, (MT), Receptors, 6777, Tocris Bioscience

1 Citation for TAK 375

Citations are publications that use Tocris products. Selected citations for TAK 375 include:

Jae-Sung et al (2019) Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end-joining repair. J Pineal Res 67 e12603 PMID: 31370106

Do you know of a great paper that uses TAK 375 from Tocris? Please let us know.

Reviews for TAK 375

Average Rating: 4 (Based on 1 Review.)

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Activates the MT receptors.
By Anonymous on 04/07/2022
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Cancer and primary liver cell lines

I used TAK 375 for cell growth analysis and western blotting analysis

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