TAK 242

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Cat.No. 6587 - TAK 242 | C15H17ClFNO4S | CAS No. 243984-11-4
Description: TLR4 signaling inhibitor
Chemical Name: (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)

Biological Activity

Toll-like receptor 4 (TLR4) signaling inhibitor. Binds to intracellular domain of TLR4. Inhibits LPS-induced cytokine production in vitro (IC50 values are 1.3, 1.3 and 3.2 nM for IL-6, TNFα and NO production). Reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs). Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Technical Data

M. Wt 361.82
Formula C15H17ClFNO4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 243984-11-4
PubChem ID 11703255
InChI Key LEEIJTHMHDMWLJ-CQSZACIVSA-N
Smiles CCOC(C1=CCCC[C@H]1S(=O)(NC2=C(C=C(C=C2)F)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.18 100
ethanol 36.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.82 mL 27.64 mL
5 mM 0.55 mL 2.76 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

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Citations for TAK 242

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Literature in this Area

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Pathways for TAK 242

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.