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Very high affinity FP receptor agonist (Ki = 0.4 nM). Reduces intraocular pressure (IOP) in animal models of ocular hypertension and normal animals.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)|
References are publications that support the biological activity of the product.
Takagi et al (2004) Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp.Eye Res. 78 767 PMID: 15037111
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Keywords: Tafluprost, Tafluprost supplier, AFP-168, AFP168, ocular, hypertension, very, high, afifinity, FP, agonists, agonism, prostaglandins, IOP, Prostanoid, Receptors, 6427, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.