Tacrine hydrochloride

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Cat.No. 0965 - Tacrine hydrochloride | C13H14N2.HCl | CAS No. 1684-40-8
Description: Cholinesterase inhibitor
Chemical Name: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Potent cholinesterase inhibitor, a cognition enhancer in vivo.

Technical Data

M. Wt 234.73
Formula C13H14N2.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1684-40-8
PubChem ID 15517
Smiles Cl.NC1=C2CCCCC2=NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 23.47 100
water 23.47 100

Preparing Stock Solutions

The following data is based on the product molecular weight 234.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.26 mL 21.3 mL 42.6 mL
5 mM 0.85 mL 4.26 mL 8.52 mL
10 mM 0.43 mL 2.13 mL 4.26 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Freeman and Dawson (1991) Tacrine: a pharmacological review. Prog.Neurobiol. 36 257 PMID: 1714613

Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137 PMID: 8558423

Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology 38 181 PMID: 10193909

Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269 PMID: 6994999

Merck Index 12 9199 PMID:

If you know of a relevant reference for Tacrine hydrochloride, please let us know.

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Keywords: Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Acetylcholine Nicotinic Receptors nAChR Muscarinic Cholinesterases

1 Citation for Tacrine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:

Rio et al (2010) M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes. Mol Cell Endocrinol 30 6011 PMID: 20427660

Do you know of a great paper that uses Tacrine hydrochloride from Tocris? If so please let us know.

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Literature in this Area


Neurodegeneration Product Guide

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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for Tacrine hydrochloride


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