Potent cholinesterase inhibitor, a cognition enhancer in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.26 mL||21.3 mL||42.6 mL|
|5 mM||0.85 mL||4.26 mL||8.52 mL|
|10 mM||0.43 mL||2.13 mL||4.26 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Freeman and Dawson (1991) Tacrine: a pharmacological review. Prog.Neurobiol. 36 257 PMID: 1714613
Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137 PMID: 8558423
Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology 38 181 PMID: 10193909
Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269 PMID: 6994999
If you know of a relevant reference for Tacrine hydrochloride, please let us know.
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Keywords: Cholinesterase inhibitors inhibits AChE Acetylcholinesterase Esterases Acetylcholine Nicotinic Receptors nAChR Muscarinic Cholinesterases
1 Citation for Tacrine hydrochloride
Citations are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:
Rio et al (2010) M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes. Mol Cell Endocrinol 30 6011 PMID: 20427660
Do you know of a great paper that uses Tacrine hydrochloride from Tocris? If so please let us know.
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