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Potent cholinesterase inhibitor, a cognition enhancer in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.26 mL||21.3 mL||42.6 mL|
|5 mM||0.85 mL||4.26 mL||8.52 mL|
|10 mM||0.43 mL||2.13 mL||4.26 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
References are publications that support the biological activity of the product.
Freeman and Dawson (1991) Tacrine: a pharmacological review. Prog.Neurobiol. 36 257 PMID: 1714613
Osborne and Christie (1996) Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 276 137 PMID: 8558423
Snape et al (1999) A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donep. and NXX-066. Neuropharmacology 38 181 PMID: 10193909
Summers and Kaufman (1980) THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 16 269 PMID: 6994999
Merck Index 12 9199
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Keywords: Tacrine hydrochloride, Tacrine hydrochloride supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Non-selective, Muscarinics, Cholinesterases, 0965, Tocris Bioscience
1 Citation for Tacrine hydrochloride
Citations are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:
Rio et al (2010) M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes. Mol Cell Endocrinol 30 6011 PMID: 20427660
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.