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Cat.No. 6757 - t-TUCB | C21H21F3N2O5 | CAS No. 948304-40-3
Description: Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Chemical Name: 4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for t-TUCB

t-TUCB is a potent soluble epoxide hydrolase (sEH) Inhibitor (IC50 = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.

Technical Data for t-TUCB

M. Wt 438.4
Formula C21H21F3N2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 948304-40-3
PubChem ID 16756850
Smiles OC(C1=CC=C(C=C1)O[C@H]2CC[C@H](NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for t-TUCB

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.84 100

Preparing Stock Solutions for t-TUCB

The following data is based on the product molecular weight 438.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.41 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References for t-TUCB

References are publications that support the biological activity of the product.

Hwang et al (2007) Orally bioavailable potent soluble epoxide hydrolase inhibitors. J.Med.Chem. 50 3825 PMID: 17616115

Deng et al (2017) Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 131 67 PMID: 28822809

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Keywords: t-TUCB, t-TUCB supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, sEH, anti-inflammatory, cardioprotective, Other, Hydrolases, 6757, Tocris Bioscience

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