T-peptide

Pricing Availability   Qty
Cat.No. 6726 - T-peptide | Ac-D-Val-D-Gln-D-Ile-D-Val-D-Tyr-D-Lys-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-NH2 | CAS No. 2022956-62-1
Description: Cytotoxic Tau peptide; cell permeable
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Peptide derived from microtubule binding repeat of Tau protein. Self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. Cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. Co-localizes with pathological hyperphosphorylated forms of tau in vitro. Cell permeable.

Technical Data

M. Wt 2195.66
Formula C92H171N45O18
Sequence VQIVYKRRRRRRRRR

(Modifications: Val-1 = N-terminal Ac, Val-1 = D-Val, Gln-2 = D-Gln, Ile-3 = D-Ile, Val-4 = D-Val, Tyr-5 = D-Tyr, Lys-6 = D-Lys, Arg-15 = C-terminal amide)

Storage Store at -20°C
CAS Number 2022956-62-1
Smiles [H]N([C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Zhao et al (2010) Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity. J.Neurosci.Res. 88 3399 PMID: 20882568

Veloria et al (2017) Novel cell model for tauopathy induced by a cell-permeable tau-related peptide ACS.Chem.Neurosci. 8 2734 PMID: 28837764


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Keywords: T-peptide, T-peptide supplier, Microtubules, 6726, Tocris Bioscience

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