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Submit ReviewT 98475
Discontinued Product
2519 has been discontinued.
View all Gonadotropin-Releasing Hormone Receptors products.
Description: GnRH receptor antagonist
Chemical Name: 7-[(2,6-Difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid 1-methylethyl ester
Purity: ≥98% (HPLC)
Biological Activity for T 98475
T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.
Technical Data for T 98475
| M. Wt | 657.77 |
| Formula | C37H37F2N3O4S |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 199119-18-1 |
| PubChem ID | 9874838 |
| InChI Key | RANJJVIMTOIWIN-UHFFFAOYSA-N |
| Smiles | CC(C)OC(=O)C1=CN(CC2=C(F)C=CC=C2F)C2=C(C(CN(C)CC3=CC=CC=C3)=C(S2)C2=CC=C(NC(=O)C(C)C)C=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for T 98475
References for T 98475
References are publications that support the biological activity of the product.
Cho et al (1998) Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor. J.Med.Chem. 41 4190 PMID: 9784092
Sasaki et al (2003) Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor. J.Med.Chem. 46 113 PMID: 12502365
Imada et al (2006) Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists. J.Med.Chem. 49 3809 PMID: 16789738
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Keywords: T 98475, T 98475 supplier, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, T98475, gonadotropin, 2519, Tocris Bioscience
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