T 98475

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Cat.No. 2519 - T 98475 | C37H37F2N3O4S | CAS No. 199119-18-1
Description: GnRH receptor antagonist
Chemical Name: 7-[(2,6-Difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid 1-methylethyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for T 98475

T 98475 is a potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.

Technical Data for T 98475

M. Wt 657.77
Formula C37H37F2N3O4S
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 199119-18-1
PubChem ID 9874838
InChI Key RANJJVIMTOIWIN-UHFFFAOYSA-N
Smiles CC(C)OC(=O)C1=CN(CC2=C(F)C=CC=C2F)C2=C(C(CN(C)CC3=CC=CC=C3)=C(S2)C2=CC=C(NC(=O)C(C)C)C=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T 98475

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.89 50

Preparing Stock Solutions for T 98475

The following data is based on the product molecular weight 657.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.04 mL 15.2 mL 30.41 mL
2.5 mM 0.61 mL 3.04 mL 6.08 mL
5 mM 0.3 mL 1.52 mL 3.04 mL
25 mM 0.06 mL 0.3 mL 0.61 mL

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Keywords: T 98475, T 98475 supplier, GnRH, receptor, antagonists, Receptors, Gonadotrophin-Releasing, Hormone, T98475, gonadotropin, 2519, Tocris Bioscience

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