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T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.
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|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574
Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152
Keywords: T 0156 hydrochloride, T 0156 hydrochloride supplier, potent, selective, PDE5, inhibitors, inhibits, Phosphodiesterases, T0156, hydrochloride, 1676, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:
Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977 PMID: 25404319
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