T 0156 hydrochloride

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Cat.No. 1676 - T 0156 hydrochloride | C31H29N5O7.HCl | CAS No. 324572-93-2
Description: Highly potent, selective PDE5 inhibitor
Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Compound Libraries

T 0156 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 620.06
Formula C31H29N5O7.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 324572-93-2
PubChem ID 9852041
InChI Key RBJCBXAXUHCWBR-UHFFFAOYSA-N
Smiles Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.59 25mM with gentle warming
ethanol 14.59 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 620.06. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.06 mL 16.13 mL
5 mM 0.32 mL 1.61 mL 3.23 mL
10 mM 0.16 mL 0.81 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and sildenafil have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152


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1 Citation for T 0156 hydrochloride

Citations are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:

Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977 PMID: 25404319


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