T 0156 hydrochloride

Discontinued Product

T 0156 hydrochloride (Cat. No. 1676) has been withdrawn from sale for commercial reasons.
Description: Highly potent, selective PDE5 inhibitor
Chemical Name: 1,2-Dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for T 0156 hydrochloride

T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Selective over 30 other enzymes and receptors (IC50 > 10 mM) and potentiates electrical field stimulation-induced relaxation of isolated rabbit corpus cavernosum. Active in vivo.

Licensing Information

Sold with the permission of Tanabe Seiyaku Co. Ltd.

Technical Data for T 0156 hydrochloride

M. Wt 620.06
Formula C31H29N5O7.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 324572-93-2
PubChem ID 9852041
Smiles Cl.COC(=O)C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C2=CC=NC(OCC3=NC=CC=N3)=C2C(=O)N1CC1=CC=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for T 0156 hydrochloride

References for T 0156 hydrochloride

References are publications that support the biological activity of the product.

Mochida et al (2002) Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur.J.Pharmacol. 456 91 PMID: 12450574

Mochida et al (2004) T-0156, a novel phosphodiesterase type 5 inhibitor, and silde. have different pharmacological effects on penile tumescence and electroretinogram in dogs. Eur.J.Pharmacol. 485 283 PMID: 14757152

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1 Citation for T 0156 hydrochloride

Citations are publications that use Tocris products. Selected citations for T 0156 hydrochloride include:

Sikka et al (2014) Melanopsin mediates light-dependent relaxation in blood vessels. J Biol Chem 111 17977 PMID: 25404319

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