SYM 2081

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Cat.No. 0903 - SYM 2081 | C6H11NO4 | CAS No. 31137-74-3
Description: Highly selective kainate agonist
Chemical Name: (2S,4R)-4-Methylglutamic acid
Purity: ≥97% (HPLC)
Citations (6)
Literature (8)

Biological Activity for SYM 2081

SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data for SYM 2081

M. Wt 161.16
Formula C6H11NO4
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 31137-74-3
PubChem ID 95883
Smiles [H][C@@](N)(C(O)=O)C[C@]([H])([C@](O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SYM 2081

Solvent Max Conc. mg/mL Max Conc. mM
water 8.06 50

Preparing Stock Solutions for SYM 2081

The following data is based on the product molecular weight 161.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 12.41 mL 62.05 mL 124.1 mL
2.5 mM 2.48 mL 12.41 mL 24.82 mL
5 mM 1.24 mL 6.21 mL 12.41 mL
25 mM 0.25 mL 1.24 mL 2.48 mL

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Product Datasheets for SYM 2081

Certificate of Analysis / Product Datasheet
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References for SYM 2081

References are publications that support the biological activity of the product.

Donevan et al (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 285 539 PMID: 9580595

Jones et al (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36 853 PMID: 9225313

Savidge et al (1999) Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 38 375 PMID: 10219975

Zhou et al (1997) (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 280 422 PMID: 8996224

If you know of a relevant reference for SYM 2081, please let us know.

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View all Kainate Receptor Agonists

Keywords: SYM 2081, SYM 2081 supplier, inhibitors, inhibits, EAAT2, kainate, receptors, agonist, selective, EAAT, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, iGluR, Ionotropic, SYM2081, Kainate, Receptors, 0903, Tocris Bioscience

6 Citations for SYM 2081

Citations are publications that use Tocris products. Selected citations for SYM 2081 include:

Pollok and Reiner (2020) Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization Proc Natl Acad Sci USA 117 25851 PMID: 32999066

Gangadharan et al (2011) Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. J Clin Invest 121 1608 PMID: 21383497

Santos et al (2009) Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PLoS One 4 e8047 PMID: 19956641

Yoshii et al (2013) A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. Addict Biol 33 8472 PMID: 23658184

Do you know of a great paper that uses SYM 2081 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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