SUN 11602

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Cat.No. 4826 - SUN 11602 | C26H37N5O2 | CAS No. 704869-38-5
Description: Basic fibroblast growth factor (bFGF) mimetic; neuroprotective
Chemical Name: 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Basic fibroblast growth factor (bFGF) mimetic. Mimics the neuroprotective effects of bFGF; prevents glutamate-induced neuronal death. Increases levels of CALB1 gene expression in cerebrocortical neurons. Triggers phosphorylation of FGFR, ERK1 and ERK2.

Compound Libraries

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Technical Data

M. Wt 451.61
Formula C26H37N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 704869-38-5
PubChem ID 22245705
InChI Key KCODNOOPOPTZMO-UHFFFAOYSA-N
Smiles NC1=C(C)C(C)=C(NCC(N(C)C2CCN(CC3=CC=C(C(N)=O)C=C3)CC2)=O)C(C)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.58 50
ethanol 9.03 20

Preparing Stock Solutions

The following data is based on the product molecular weight 451.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.07 mL 22.14 mL
5 mM 0.44 mL 2.21 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the products' biological activity.

Murayama et al (2013) SUN11602, a novel aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. ACS Chem.Neurosci. 4 266 PMID: 23421678


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Keywords: SUN11602 basic fibroblast growth factor bFGF calcium binding protein calbindin-D28k Calb FGFR receptor ERK1 ERK2 FGFR

Citations for SUN 11602

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