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Cat.No. 6337 - Sulopenem | C12H15NO5S3 | CAS No. 120788-07-0
Description: Penem antibiotic
Chemical Name: (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Purity: ≥98% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

Penem antibiotic. Exhibits potent antibacterial activity against a range of Gram-positive and -negative bacteria (MIC90s < 1 μg/ml), except MRSA, Pseudomonas aeruginosa and Xanthomonas maltophilia.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 349.45
Formula C12H15NO5S3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 120788-07-0
PubChem ID 71341
Smiles C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(S2)SC3CCS(=O)C3)C(=O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.94 100
1.1eq. NaOH 34.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 349.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References are publications that support the biological activity of the product.

Minamimura et al (1993) In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic. Antimicrob.Agents Chemother. 37 1547 PMID: 8363389

Gootz et al (1989) In vitro activity of CP-65,207, a new penem antimicrobial agent, in comparison with those of other agents. Antimicrob.Agents Chemother 33 1160 PMID: 2679370

If you know of a relevant reference for Sulopenem, please let us know.

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Keywords: Sulopenem, Sulopenem supplier, potent, antibiotics, penems, beta, lactams, Antibiotics, 6337, Tocris Bioscience

Citations for Sulopenem

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Sulopenem to study highly resistant strains of E.Coli.
By Anonymous on 12/13/2018
Species: Human

I have used Sulopenem to study highly resistant strains of E.Coli over a period of incubation time.

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Literature in this Area

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