Sulfisoxazole

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Cat.No. 0731 - Sulfisoxazole | C11H13N3O3S | CAS No. 127-69-5
Description: Endothelin ETA antagonist
Chemical Name: 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

A selective ETA endothelin receptor antagonist (IC50 values are 600 and 2200 nM for ETA and ETB receptors respectively).

Technical Data

M. Wt 267.3
Formula C11H13N3O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 127-69-5
PubChem ID 5344
InChI Key NHUHCSRWZMLRLA-UHFFFAOYSA-N
Smiles CC1=NOC(NS(=O)(=O)C2=CC=C(N)C=C2)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.71 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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References

References are publications that support the biological activity of the product.

Chan et al (1994) Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem.Biophys.Res.Commun. 201 228 PMID: 8198578


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Keywords: Sulfisoxazole, Sulfisoxazole supplier, Endothelin, ETA, antagonists, Receptors, 0731, Tocris Bioscience

Citations for Sulfisoxazole

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Literature in this Area

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