SU 9516

Discontinued Product

SU 9516 (Cat. No. 2907) has been withdrawn from sale for commercial reasons.
Description: Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name: (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for SU 9516

SU 9516 is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 μM for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro.

Technical Data for SU 9516

M. Wt 241.25
Formula C13H11N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 377090-84-1
PubChem ID 5289419
Smiles O=C2NC1=CC=C(OC)C=C1/C2=C/C3=CNC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SU 9516

Certificate of Analysis / Product Datasheet
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Keywords: SU 9516, SU 9516 supplier, Potent, cdk2, inhibitors, inhibits, Transcriptionally, downregulates, Mcl-1, proapoptotic, Cyclin-Dependent, Protein, Kinases, Bcl-2, Family, SU9516, Cyclin-dependent, Kinase, Non-selective, CDKs, 2907, Tocris Bioscience

2 Citations for SU 9516

Citations are publications that use Tocris products. Selected citations for SU 9516 include:

Shi et al (2014) The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med 18 2061 PMID: 25124967

Pollet et al (2018) The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25 1823 PMID: 30013037

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