SU 9516

Pricing Availability   Qty
Description: Cdk inhibitor; potently inhibits cdk1 and cdk2
Chemical Name: (Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-indol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for SU 9516

SU 9516 is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 0.02 - 0.03, 0.04 - 0.2, 0.2 - 1.7 and 0.9 μM for cdk2, cdk1, cdk4 and cdk9, respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and pro-apoptotic effects in vitro.

Compound Libraries for SU 9516

SU 9516 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SU 9516

M. Wt 241.25
Formula C13H11N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 377090-84-1
PubChem ID 5289419
InChI Key QNUKRWAIZMBVCU-WCIBSUBMSA-N
Smiles O=C2NC1=CC=C(OC)C=C1/C2=C/C3=CNC=N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SU 9516

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.12 100
ethanol 4.83 20

Preparing Stock Solutions for SU 9516

The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.15 mL 20.73 mL 41.45 mL
5 mM 0.83 mL 4.15 mL 8.29 mL
10 mM 0.41 mL 2.07 mL 4.15 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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Product Datasheets for SU 9516

Certificate of Analysis / Product Datasheet
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View Related Products by Product Action

View all Non-selective CDK Inhibitors

Keywords: SU 9516, SU 9516 supplier, Potent, cdk2, inhibitors, inhibits, Transcriptionally, downregulates, Mcl-1, proapoptotic, Cyclin-Dependent, Protein, Kinases, Bcl-2, Family, SU9516, Cyclin-dependent, Kinase, Non-selective, CDKs, 2907, Tocris Bioscience

2 Citations for SU 9516

Citations are publications that use Tocris products. Selected citations for SU 9516 include:

Pollet et al (2018) The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25 1823 PMID: 30013037

Shi et al (2014) The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med 18 2061 PMID: 25124967


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