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SU 6668

Cat. No. 3335 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PDGFR, VEGFR and FGFR inhibitor
Alternative Names: TSU68, Orantinib
Chemical Name: 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SU 6668

SU 6668 is an ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Technical Data for SU 6668

M. Wt 310.35
Formula C18H18N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 252916-29-3
PubChem ID 5329099
InChI Key NHFDRBXTEDBWCZ-ZROIWOOFSA-N
Smiles O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SU 6668

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 31.03 100
DMSO 31.03 100

Preparing Stock Solutions for SU 6668

The following data is based on the product molecular weight 310.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.11 mL 32.22 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References for SU 6668

References are publications that support the biological activity of the product.

Sun et al (1999) Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697

Laird et al (2000) SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 60 4152 PMID: 10945623

Yamamoto et al (2008) TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res. 68 9754 PMID: 19047154

If you know of a relevant reference for SU 6668, please let us know.

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Keywords: SU 6668, SU 6668 supplier, FGFR, VEGFR, PDGFR, inhibitors, inhibits, Fibroblast, Growth, Factor, Receptors, Receptor, Tyrosine, Kinases, RTKs, Platelet, Derived, Vascular, Endothelial, KDR, Flt, SU6668, TSU68, Orantinib, 3335, Tocris Bioscience

2 Citations for SU 6668

Citations are publications that use Tocris products. Selected citations for SU 6668 include:

Yan et al (2017) Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep 7 45796 PMID: 28378824

Mathew et al (2015) Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Mol Biol Cell 8 ra42 PMID: 25943352

Do you know of a great paper that uses SU 6668 from Tocris? Please let us know.

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Literature in this Area

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