SU 4312

Discontinued Product

SU 4312 (Cat. No. 1459) has been withdrawn from sale for commercial reasons.
Cat.No. 1459 - SU 4312 | C17H16N2O | CAS No. 5812-07-7
Description: Potent inhibitor of VEGFR tyrosine kinase
Alternative Names: DMBI
Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
Datasheet
Citations (1)
Reviews
Literature (3)
Pathways (1)

Biological Activity for SU 4312

SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.

Technical Data for SU 4312

M. Wt 264.33
Formula C17H16N2O
Storage Desiccate at -20°C
CAS Number 5812-07-7
PubChem ID 6450842
InChI Key UAKWLVYMKBWHMX-PTNGSMBKSA-N
Smiles CN(C)C1=CC=C(C=C1)\C=C1/C(=O)NC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: SU 4312, SU 4312 supplier, Potent, inhibitors, inhibits, VEGFR, tyrosine, kinase, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, SU4312, DMBI, 1459, Tocris Bioscience

1 Citation for SU 4312

Citations are publications that use Tocris products. Selected citations for SU 4312 include:

Cole et al (2010) Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis. PLoS One 5 e11644 PMID: 20657775


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for SU 4312

VEGF

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.