SU 11274

Discontinued Product

SU 11274 (Cat. No. 4101) has been withdrawn from sale for commercial reasons.
Cat.No. 4101 - SU 11274 | C28H30ClN5O4S | CAS No. 658084-23-2
Description: Selective inhibitor of MET kinase activity
Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
Purity: ≥97% (HPLC)
Citations (5)
Literature (2)

Biological Activity

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

Technical Data

M. Wt 568.09
Formula C28H30ClN5O4S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 658084-23-2
PubChem ID 9549297
Smiles CC1=C(\C=C(C3=CC(S(N(C)C5=CC(Cl)=CC=C5)(=O)=O)=CC=C3N4)/C4=O)NC(C)=C1C(N2CCN(C)CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases