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Submit ReviewSTOCK2S 26016
Description: Lysine deficient protein kinase (WNK) signaling inhibitor
Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
Purity: ≥98% (HPLC)
Biological Activity for STOCK2S 26016
STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively. Inhibits STK39 activation; inhibits migration and invasion of cancer cells in vitro.
Technical Data for STOCK2S 26016
| M. Wt | 333.38 |
| Formula | C20H19N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 332922-63-1 |
| PubChem ID | 3135086 |
| InChI Key | PGNWQNJXXLPZEL-UHFFFAOYSA-N |
| Smiles | NC1=C2C(C=CC(OCC)=C2)=NC3=C1C=CC(NCC4=CC=CO4)=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for STOCK2S 26016
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.34 | 100 | |
| ethanol | 16.67 | 50 |
Preparing Stock Solutions for STOCK2S 26016
The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3 mL | 15 mL | 30 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for STOCK2S 26016
References for STOCK2S 26016
References are publications that support the biological activity of the product.
Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339 PMID: 23981180
Qiu et al (2021) STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. Theranostics 11 7658 PMID: 34335956
If you know of a relevant reference for STOCK2S 26016, please let us know.
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Keywords: STOCK2S 26016, STOCK2S 26016 supplier, with, no, lysine, deficient, protein, kinase, WNK1, WNK4, SPAK, signaling, inhibitors, inhibits, antihypertensive, Other, Kinases, 5570, Tocris Bioscience
3 Citations for STOCK2S 26016
Citations are publications that use Tocris products. Selected citations for STOCK2S 26016 include:
Lu et al (2019) The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia. Pflugers Arch. 471 1539 PMID: 31729557
Hortle et al (2022) OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Sci.Alliance 5 e202201476 PMID: 35545295
Qiu et al (2021) STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. Theranostics 11 7658 PMID: 34335956
Do you know of a great paper that uses STOCK2S 26016 from Tocris? Please let us know.
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