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Biological Activity for STOCK2S 26016
STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.
Technical Data for STOCK2S 26016
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for STOCK2S 26016
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for STOCK2S 26016
The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3 mL||15 mL||30 mL|
|5 mM||0.6 mL||3 mL||6 mL|
|10 mM||0.3 mL||1.5 mL||3 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References for STOCK2S 26016
References are publications that support the biological activity of the product.
Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339 PMID: 23981180
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Citations for STOCK2S 26016
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Literature in this Area
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