STOCK2S 26016

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Cat.No. 5570 - STOCK2S 26016 | C20H19N3O2 | CAS No. 332922-63-1
Description: Lysine deficient protein kinase (WNK) signaling inhibitor
Chemical Name: 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively.

Technical Data

M. Wt 333.38
Formula C20H19N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 332922-63-1
PubChem ID 3135086
InChI Key PGNWQNJXXLPZEL-UHFFFAOYSA-N
Smiles NC1=C2C(C=CC(OCC)=C2)=NC3=C1C=CC(NCC4=CC=CO4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.34 100
ethanol 16.67 50

Preparing Stock Solutions

The following data is based on the product molecular weight 333.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References

References are publications that support the biological activity of the product.

Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339 PMID: 23981180


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