STING agonist C53

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Description: Pan-polymorph STING agonist
Chemical Name: 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for STING agonist C53

STING agonist C53 is an activator of human STING (EC50 = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

Compound Libraries for STING agonist C53

STING agonist C53 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for STING agonist C53

M. Wt 490.88
Formula C25H19ClF4N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2259624-71-8
PubChem ID 137367538
Smiles CC1(C(N(C2=CC(C(NCC3=C(C=C(C=C3F)F)F)=O)=CC=C12)CC4=C(C=CC=C4F)Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STING agonist C53

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.09 100

Preparing Stock Solutions for STING agonist C53

The following data is based on the product molecular weight 490.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.37 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets for STING agonist C53

References for STING agonist C53

References are publications that support the biological activity of the product.

Pryde et al (2021) The discovery of potent small molecule activators of human STING. Eur.J.Med.Chem. 209 112869 PMID: 33038794

Lu et al (2022) Activation of STING by targeting a pocket in the transmembrane domain. Nature 604 557 PMID: 35388221

If you know of a relevant reference for STING agonist C53, please let us know.

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Citations for STING agonist C53

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