STING agonist C53

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 7741 - STING agonist C53 | C25H19ClF4N2O2 | CAS No. 2259624-71-8
Description: Pan-polymorph STING agonist
Chemical Name: 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for STING agonist C53

STING agonist C53 is an activator of human STING (EC50 = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

Technical Data for STING agonist C53

M. Wt 490.88
Formula C25H19ClF4N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2259624-71-8
PubChem ID 137367538
InChI Key OEBVYNULNKSONR-UHFFFAOYSA-N
Smiles CC1(C(N(C2=CC(C(NCC3=C(C=C(C=C3F)F)F)=O)=CC=C12)CC4=C(C=CC=C4F)Cl)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STING agonist C53

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.09 100

Preparing Stock Solutions for STING agonist C53

The following data is based on the product molecular weight 490.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.37 mL
5 mM 0.41 mL 2.04 mL 4.07 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for STING agonist C53

References for STING agonist C53

References are publications that support the biological activity of the product.

Pryde et al (2021) The discovery of potent small molecule activators of human STING. Eur.J.Med.Chem. 209 112869 PMID: 33038794

Lu et al (2022) Activation of STING by targeting a pocket in the transmembrane domain. Nature 604 557 PMID: 35388221


If you know of a relevant reference for STING agonist C53, please let us know.

View Related Products by Target

View Related Products by Product Action

View all STING-Dependent Signaling Agonists

Keywords: STING agonist C53, STING agonist C53 supplier, stingagonistc53, Promotes, promoters, oligomerization, activation, human, STING, pan, polymorph, STING-Dependent, Signaling, 7741, Tocris Bioscience

Citations for STING agonist C53

Citations are publications that use Tocris products.

Currently there are no citations for STING agonist C53. Do you know of a great paper that uses STING agonist C53 from Tocris? Please let us know.

Reviews for STING agonist C53

There are currently no reviews for this product. Be the first to review STING agonist C53 and earn rewards!

Have you used STING agonist C53?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation