SSR 180711 hydrochloride

Pricing Availability   Qty
Description: Selective α7 nAChR partial agonist
Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for SSR 180711 hydrochloride

SSR 180711 hydrochloride is a partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.

Technical Data for SSR 180711 hydrochloride

M. Wt 361.66
Formula C14H17BrN2O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 446031-79-4
PubChem ID 9928899
Smiles O=C(N1C2CCN(CC2)CC1)OC3=CC=C(Br)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SSR 180711 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 36.17 100
DMSO 36.17 100

Preparing Stock Solutions for SSR 180711 hydrochloride

The following data is based on the product molecular weight 361.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for SSR 180711 hydrochloride

References for SSR 180711 hydrochloride

References are publications that support the biological activity of the product.

Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673 PMID: 24057763

Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17 PMID: 16936709

If you know of a relevant reference for SSR 180711 hydrochloride, please let us know.

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Citations for SSR 180711 hydrochloride

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Literature in this Area

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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