SSR 180711 hydrochloride

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Cat.No. 5559 - SSR 180711 hydrochloride | C14H17BrN2O2.HCl | CAS No. 446031-79-4
Description: Partial agonist at α7 nAChR
Chemical Name: 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Partial agonist at α7 nAChR. Enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. Increases extracellular dopamine levels in rat prefrontal cortex. Also exhibits antidepressant-like properties.

Compound Libraries

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Technical Data

M. Wt 361.66
Formula C14H17BrN2O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 446031-79-4
PubChem ID 9928899
InChI Key YNBXNVUZXFMNSJ-UHFFFAOYSA-N
Smiles O=C(N1C2CCN(CC2)CC1)OC3=CC=C(Br)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.17 100
water 36.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.65 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jones et al (2014) Effect of α7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats. Psychopharmacology (Berl). 231 673 PMID: 24057763

Pichat et al (2007) SSR180711, a novel selective α7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32 17 PMID: 16936709


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Citations for SSR 180711 hydrochloride

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