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SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
SSM 3 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 952.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.05 mL||5.25 mL||10.5 mL|
|5 mM||0.21 mL||1.05 mL||2.1 mL|
|10 mM||0.1 mL||0.52 mL||1.05 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the biological activity of the product.
Remacle (2010) Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int.J.Biochem.Cell Biol. 42 987 PMID: 20197107
If you know of a relevant reference for SSM 3 trifluoroacetate, please let us know.
Keywords: SSM 3 trifluoroacetate, SSM 3 trifluoroacetate supplier, SSM3, SSM, 3, trifluoroacetate, furin, inhibitors, inhibits, SSM-3, 922732-52-3, Furin, 5253, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SSM 3 trifluoroacetate include:
Hervouet et al (2022) An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell. PLoS Pathog. 18 e1010798 PMID: 36007070
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239
Do you know of a great paper that uses SSM 3 trifluoroacetate from Tocris? Please let us know.
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