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SSM 3 trifluoroacetate
Potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 952.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.05 mL||5.25 mL||10.5 mL|
|5 mM||0.21 mL||1.05 mL||2.1 mL|
|10 mM||0.1 mL||0.52 mL||1.05 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References are publications that support the biological activity of the product.
Remacle (2010) Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int.J.Biochem.Cell Biol. 42 987 PMID: 20197107
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1 Citation for SSM 3 trifluoroacetate
Citations are publications that use Tocris products. Selected citations for SSM 3 trifluoroacetate include:
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239
Do you know of a great paper that uses SSM 3 trifluoroacetate from Tocris? Please let us know.
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