SSM 3 trifluoroacetate

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Description: Potent furin inhibitor
Chemical Name: rel-N,N''-[[(1R,3S,4S,6R)-4,6-Bis[(aminoiminomethyl)amino]-1,3-cyclohexanedyil]bis(oxy-4,1-phenylene)]bisguanidine tetratrifluoroacetate salt
Purity: ≥98% (HPLC)
Citations (3)

Biological Activity for SSM 3 trifluoroacetate

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

Compound Libraries for SSM 3 trifluoroacetate

SSM 3 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SSM 3 trifluoroacetate

M. Wt 952.66
Formula C22H32N12O2.4CF3CO2H
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2320930-10-5
PubChem ID 121513857
Smiles NC(N[C@H]1C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C[C@@H]1OC2=CC=C(NC(N)=N)C=C2)=N.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SSM 3 trifluoroacetate

Solvent Max Conc. mg/mL Max Conc. mM
water 49.66 100
DMSO 49.66 100

Preparing Stock Solutions for SSM 3 trifluoroacetate

The following data is based on the product molecular weight 952.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.25 mL 10.5 mL
5 mM 0.21 mL 1.05 mL 2.1 mL
10 mM 0.1 mL 0.52 mL 1.05 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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Product Datasheets for SSM 3 trifluoroacetate

Certificate of Analysis / Product Datasheet
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References for SSM 3 trifluoroacetate

References are publications that support the biological activity of the product.

Remacle (2010) Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int.J.Biochem.Cell Biol. 42 987 PMID: 20197107

If you know of a relevant reference for SSM 3 trifluoroacetate, please let us know.

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Keywords: SSM 3 trifluoroacetate, SSM 3 trifluoroacetate supplier, SSM3, SSM, 3, trifluoroacetate, furin, inhibitors, inhibits, SSM-3, 922732-52-3, Furin, 5253, Tocris Bioscience

3 Citations for SSM 3 trifluoroacetate

Citations are publications that use Tocris products. Selected citations for SSM 3 trifluoroacetate include:

Hervouet et al (2022) An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell. PLoS Pathog. 18 e1010798 PMID: 36007070

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239

Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839

Do you know of a great paper that uses SSM 3 trifluoroacetate from Tocris? Please let us know.

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