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Selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 626.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||7.98 mL||39.9 mL||79.79 mL|
|1 mM||1.6 mL||7.98 mL||15.96 mL|
|2 mM||0.8 mL||3.99 mL||7.98 mL|
|10 mM||0.16 mL||0.8 mL||1.6 mL|
References are publications that support the biological activity of the product.
Flaveny et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 28 42 PMID: 26120082
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Keywords: SR 9243, SR 9243 supplier, SR9243, selective, LXR, inverse, agonists, agonism, lipogenesis, Warburg, effect, LXR-like, Receptors, 6138, Tocris Bioscience
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