SR 9243

Pricing Availability   Qty
Description: Selective LXR inverse agonist
Chemical Name: N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
Purity: ≥98% (HPLC)

Biological Activity for SR 9243

SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

Technical Data for SR 9243

M. Wt 626.62
Formula C31H32BrNO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1613028-81-1
PubChem ID 76073169
Smiles CC1=CC(C)=CC(C)=C1S(N(CCC2=CC=CC(Br)=C2)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 9243

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.53 20

Preparing Stock Solutions for SR 9243

The following data is based on the product molecular weight 626.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.98 mL 39.9 mL 79.79 mL
1 mM 1.6 mL 7.98 mL 15.96 mL
2 mM 0.8 mL 3.99 mL 7.98 mL
10 mM 0.16 mL 0.8 mL 1.6 mL

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References for SR 9243

References are publications that support the biological activity of the product.

Flaveny et al (2015) Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 28 42 PMID: 26120082

If you know of a relevant reference for SR 9243, please let us know.

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Keywords: SR 9243, SR 9243 supplier, SR9243, selective, LXR, inverse, agonists, agonism, lipogenesis, Warburg, effect, LXR-like, Receptors, 6138, Tocris Bioscience

Citations for SR 9243

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