SR 57227 hydrochloride

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Cat.No. 1205 - SR 57227 hydrochloride | C10H14ClN3.HCl | CAS No. 77145-61-0
Description: Potent, selective 5-HT3 agonist
Chemical Name: 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)

Biological Activity

A high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant.

Technical Data

M. Wt 248.15
Formula C10H14ClN3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 77145-61-0
PubChem ID 131746
Smiles Cl.NC1CCN(CC1)C1=NC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.82 100
water 50

Preparing Stock Solutions

The following data is based on the product molecular weight 248.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.15 mL 40.3 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Bachy et al (1993) SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur.J.Pharmacol. 237 299 PMID: 7689975

Edwards et al (1996) 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 733 21 PMID: 8891244

If you know of a relevant reference for SR 57227 hydrochloride, please let us know.

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1 Citation for SR 57227 hydrochloride

Citations are publications that use Tocris products. Selected citations for SR 57227 hydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Dent Res J (Isfahan) 7 2336 PMID: 26114334

Do you know of a great paper that uses SR 57227 hydrochloride from Tocris? If so please let us know.

Reviews for SR 57227 hydrochloride

Average Rating: 4 (Based on 1 Review)

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PGE2 release
By jialie luo on 01/10/2018
Assay Type: In Vitro
Species: Mouse

SR 57227 hydrochloride was used to stimulate macrophages as negative control.

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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.