SR 57227 hydrochloride

Pricing Availability   Qty
Description: Potent and selective 5-HT3 agonist
Chemical Name: 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)
Literature (1)

Biological Activity for SR 57227 hydrochloride

SR 57227 hydrochloride is a high affinity, selective 5-HT3 receptor agonist, active in vivo and CNS penetrant.

Technical Data for SR 57227 hydrochloride

M. Wt 248.15
Formula C10H14ClN3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 77145-61-0
PubChem ID 131746
Smiles Cl.NC1CCN(CC1)C1=NC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 57227 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 24.82 100
DMSO 24.82 100

Preparing Stock Solutions for SR 57227 hydrochloride

The following data is based on the product molecular weight 248.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.15 mL 40.3 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets for SR 57227 hydrochloride

Certificate of Analysis / Product Datasheet
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References for SR 57227 hydrochloride

References are publications that support the biological activity of the product.

Bachy et al (1993) SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur.J.Pharmacol. 237 299 PMID: 7689975

Edwards et al (1996) 5-HT3-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 733 21 PMID: 8891244

If you know of a relevant reference for SR 57227 hydrochloride, please let us know.

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1 Citation for SR 57227 hydrochloride

Citations are publications that use Tocris products. Selected citations for SR 57227 hydrochloride include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Dent Res J (Isfahan) 7 2336 PMID: 26114334

Do you know of a great paper that uses SR 57227 hydrochloride from Tocris? Please let us know.

Reviews for SR 57227 hydrochloride

Average Rating: 4 (Based on 1 Review.)

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PGE2 release.
By jialie luo on 01/10/2018
Assay Type: In Vitro
Species: Mouse

SR 57227 hydrochloride was used to stimulate macrophages as negative control.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.