SR 202

Pricing Availability   Qty
Description: Selective PPARγ antagonist; antidiabetic and antiobesity agent
Alternative Names: Mifobate
Chemical Name: (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for SR 202

SR 202 is a selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.

Technical Data for SR 202

M. Wt 358.65
Formula C11H17ClO7P2
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 76541-72-5
PubChem ID 60910
InChI Key VQHUQHAPWMNBLP-UHFFFAOYSA-N
Smiles COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 202

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.87 100

Preparing Stock Solutions for SR 202

The following data is based on the product molecular weight 358.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.94 mL 27.88 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for SR 202

References are publications that support the biological activity of the product.

Nguyen et al (1987) gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity. J.Med.Chem. 30 1426 PMID: 3612689

Rieusset et al (2002) A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol.Endocrinol. 16 2628 PMID: 12403851

Doggrell (2003) Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs? Expert.Opin.Invest.Drugs 12 713


If you know of a relevant reference for SR 202, please let us know.

View Related Products by Target

View Related Products by Product Action

View all PPARγ Antagonists

Keywords: SR 202, SR 202 supplier, Selective, PPARγ, PPARgamma, antagonists, antidiabetic, antiobesity, agent, Peroxisome, Proliferator-activating, Receptors, SR202, Mifobate, 2022, Tocris Bioscience

Citations for SR 202

Citations are publications that use Tocris products.

Currently there are no citations for SR 202. Do you know of a great paper that uses SR 202 from Tocris? Please let us know.

Reviews for SR 202

There are currently no reviews for this product. Be the first to review SR 202 and earn rewards!

Have you used SR 202?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review