SR 1664

Discontinued Product

SR 1664 (Cat. No. 4409) has been withdrawn from sale for commercial reasons.
Description: High affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation
Chemical Name: 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥97% (HPLC)
Literature (4)

Biological Activity for SR 1664

SR 1664 is an antidiabetic agent; binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. Does not inhibit Cdk5-dependent phosphorylation of Rb. Reduces fasting insulin levels and improves insulin sensitivity in a mouse model of diabetes.

Technical Data for SR 1664

M. Wt 547.6
Formula C33H29N3O5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1338259-05-4
PubChem ID 53239854
Smiles CC2=C(C)N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C1=CC=C(C(N[C@H](C5=CC=C([N+]([O-])=O)C=C5)C)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SR 1664

Certificate of Analysis / Product Datasheet
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References for SR 1664

References are publications that support the biological activity of the product.

Norris and Sigmund (2012) A second chance for a PPARγ targeted therapy? Circ.Res. 110 8 PMID: 22223206

Choi et al (2011) Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature 477 477 PMID: 21892191

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Keywords: SR 1664, SR 1664 supplier, SR1664, antidiabetics, diabetes, PPARgamma, PPARg, peroxisome, proliferator, activated, receptor, ligand, Cdk5, phosphorylation, LBD, Receptors, 4409, Tocris Bioscience

Citations for SR 1664

Citations are publications that use Tocris products.

Currently there are no citations for SR 1664.

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