Agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.
Sold under license from The Scripps Research Institute.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 431.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.32 mL||11.59 mL||23.19 mL|
|5 mM||0.46 mL||2.32 mL||4.64 mL|
|10 mM||0.23 mL||1.16 mL||2.32 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the products' biological activity.
Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029 PMID: 20735016
Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921 PMID: 22509368
If you know of a relevant reference for SR 1078, please let us know.
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Keywords: SR 1078, supplier, SR1078, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, agonists, Retinoic, Acid-related, Orphan, Receptors, Retinoic, Acid-related, Orphan, Receptors, Tocris Bioscience
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