SR 1078

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Cat.No. 4874 - SR 1078 | C17H10F9NO2 | CAS No. 1246525-60-9
Description: RORα/γ agonist
Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries

SR 1078 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 431.25
Formula C17H10F9NO2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1246525-60-9
PubChem ID 17980288
InChI Key DUXWIYXHHGNUJU-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1NC(C2=CC=C(C(F)(F)F)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.12 100
ethanol 43.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 431.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.19 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029 PMID: 20735016

Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921 PMID: 22509368


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Citations for SR 1078

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Literature in this Area

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Nuclear Receptors

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