SR 10067

Pricing Availability Delivery Time Qty
Cat.No. 6038 - SR 10067 | C31H31NO3 | CAS No. 1380548-02-6
Description: Selective Rev-Erbα/β agonist; anxiolytic
Chemical Name: [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

Technical Data

M. Wt 465.58
Formula C31H31NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1380548-02-6
PubChem ID 60168097
InChI Key MOPAGKWBFUICQT-UHFFFAOYSA-N
Smiles CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.33 5mM with gentle warming
ethanol 2.33 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 465.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Banerjee et al (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 23 5759 PMID: 25536025

Thevis et al (2016) Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 30 635 PMID: 26842585


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Keywords: SR 10067, supplier, SR10067, SR_10067, Selective, REV-ERBab, REV-ERBa, REV-ERBb, REV-ERBalpha, REV-ERBbeta, REV-ERBα/β, agonists, agonism, sleep, circadian, rhythm, anxiety, anxiolytics, Rev-Erb, Receptors, Rev-Erb, Receptors, Tocris Bioscience

Citations for SR 10067

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Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

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