SR 10067

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Description: Selective Rev-Erbα/β agonist; anxiolytic
Chemical Name: [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
Purity: ≥98% (HPLC)

Biological Activity for SR 10067

SR 10067 is a selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

Technical Data for SR 10067

M. Wt 465.58
Formula C31H31NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1380548-02-6
PubChem ID 60168097
Smiles CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SR 10067

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 2.33 5 with gentle warming

Preparing Stock Solutions for SR 10067

The following data is based on the product molecular weight 465.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 42.96 mL 214.79 mL 429.57 mL
0.25 mM 8.59 mL 42.96 mL 85.91 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
2.5 mM 0.86 mL 4.3 mL 8.59 mL

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References for SR 10067

References are publications that support the biological activity of the product.

Banerjee et al (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 23 5759 PMID: 25536025

Thevis et al (2016) Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 30 635 PMID: 26842585

If you know of a relevant reference for SR 10067, please let us know.

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Keywords: SR 10067, SR 10067 supplier, SR10067, SR_10067, Selective, REV-ERBab, REV-ERBa, REV-ERBb, REV-ERBalpha, REV-ERBbeta, REV-ERBα/β, agonists, agonism, sleep, circadian, rhythm, anxiety, anxiolytics, Rev-Erb, Receptors, 6038, Tocris Bioscience

Citations for SR 10067

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