Selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.33||5mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the products' biological activity.
Banerjee et al (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 23 5759 PMID: 25536025
Thevis et al (2016) Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 30 635 PMID: 26842585
If you know of a relevant reference for SR 10067, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 10067, supplier, SR10067, SR_10067, Selective, REV-ERBab, REV-ERBa, REV-ERBb, REV-ERBalpha, REV-ERBbeta, REV-ERBα/β, agonists, agonism, sleep, circadian, rhythm, anxiety, anxiolytics, Rev-Erb, Receptors, Rev-Erb, Receptors, Tocris Bioscience
Citations for SR 10067
Citations are publications that use Tocris products.
Currently there are no citations for SR 10067. Do you know of a great paper that uses SR 10067 from Tocris? If so please let us know.
Reviews for SR 10067
There are currently no reviews for this product. Be the first to review SR 10067 and earn rewards!
Have you used SR 10067?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.