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Biological Activity for SR 1001
Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
Sold under license from The Scripps Research Institute.
Compound Libraries for SR 1001
Technical Data for SR 1001
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for SR 1001
References are publications that support the biological activity of the product.
Solt et al (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472 491 PMID: 21499262
Crumbley et al (2012) Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS ONE 7 33804 PMID: 22485150
Beurel et al (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol.Psychiatry 73 622 PMID: 23174342
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Keywords: SR 1001, SR 1001 supplier, SR1001, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, inverse, agonists, Retinoic, Acid-related, Orphan, Receptors, 4868, Tocris Bioscience
Citations for SR 1001
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Currently there are no citations for SR 1001.
Reviews for SR 1001
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Literature in this Area
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