SR 1001

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Cat.No. 4868 - SR 1001 | C15H13F6N3O4S2 | CAS No. 1335106-03-0
Description: RORα/γ inverse agonist
Chemical Name: N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries

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Technical Data

M. Wt 477.4
Formula C15H13F6N3O4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1335106-03-0
PubChem ID 44241473
Smiles CC1=C(S(NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2)(=O)=O)SC(NC(C)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.74 100
ethanol 47.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 477.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL
10 mM 0.21 mL 1.05 mL 2.09 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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References are publications that support the biological activity of the product.

Solt et al (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472 491 PMID: 21499262

Crumbley et al (2012) Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS ONE 7 33804 PMID: 22485150

Beurel et al (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol.Psychiatry 73 622 PMID: 23174342

If you know of a relevant reference for SR 1001, please let us know.

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