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Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.
Sold under license from the Children's Medical Center Corporation.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 262.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.81 mL||19.06 mL||38.12 mL|
|5 mM||0.76 mL||3.81 mL||7.62 mL|
|10 mM||0.38 mL||1.91 mL||3.81 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Haruki et al (2016) Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid. J.Biol.Chem. 291 652 PMID: 26565027
Latremoliere et al (2015) Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway. Neuron 86 1393 PMID: 26087165
Cronin et al (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563 564 PMID: 30405245
If you know of a relevant reference for SPRi 3, please let us know.
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Keywords: SPRi 3, SPRi 3 supplier, SPRi3, sepiapterin, reductase, SPR, inhibitors, inhibits, tetrahydrobiopterin, pathway, BH4, Tcells, T, cells, CD4+, Other, Reductase, 6597, Tocris Bioscience
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