You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.
Sold under license from the Children's Medical Center Corporation.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 262.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.81 mL||19.06 mL||38.12 mL|
|5 mM||0.76 mL||3.81 mL||7.62 mL|
|10 mM||0.38 mL||1.91 mL||3.81 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Haruki et al (2016) Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid. J.Biol.Chem. 291 652 PMID: 26565027
Latremoliere et al (2015) Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway. Neuron 86 1393 PMID: 26087165
Cronin et al (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563 564 PMID: 30405245
If you know of a relevant reference for SPRi 3, please let us know.
View Related Products by Product Action
Keywords: SPRi 3, SPRi 3 supplier, SPRi3, sepiapterin, reductase, SPR, inhibitors, inhibits, tetrahydrobiopterin, pathway, BH4, Tcells, T, cells, CD4+, Other, Reductase, 6597, Tocris Bioscience
Citations for SPRi 3
Citations are publications that use Tocris products.
Currently there are no citations for SPRi 3. Do you know of a great paper that uses SPRi 3 from Tocris? Please let us know.
Reviews for SPRi 3
There are currently no reviews for this product. Be the first to review SPRi 3 and earn rewards!
Have you used SPRi 3?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells