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Description: S-Nitrosoglutathione reductase inhibitor
Chemical Name: 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity
S-Nitrosoglutathione reductase inhibitor. Prevents weight loss, and attenuates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.
Technical Data
| M. Wt | 433.5 |
| Formula | C22H15N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 688347-51-5 |
| PubChem ID | 3651705 |
| InChI Key | UWWSCLNCHCROLL-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=C(C=C1)CN2C(C3=C(N=C2SCC4=C(C#N)C=CC=C4)C=CS3)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.35 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 433.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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References
References are publications that support the biological activity of the product.
Luzina et al (2015) Pharmacological in vivo inhibition of S-nitrosoglutathione reductase attenuates bleomycin-induced inflammation and fibrosis. J.Pharmacol.Exp.Ther. 355 13 PMID: 26209236
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Keywords: SPL 334, SPL 334 supplier, SPL334, S-nitrosoglutathione, reductase, inhibitors, inhibits, interstitial, lung, disease, Other, Dehydrogenases, 5809, Tocris Bioscience
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