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Submit ReviewSPL 334
Discontinued Product
SPL 334 (Cat. No. 5809) has been withdrawn from sale for commercial reasons.
Description: S-Nitrosoglutathione reductase inhibitor
Chemical Name: 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for SPL 334
SPL 334 is a S-Nitrosoglutathione reductase inhibitor. Prevents weight loss, and attenuates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.
Technical Data for SPL 334
| M. Wt | 433.5 |
| Formula | C22H15N3O3S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 688347-51-5 |
| PubChem ID | 3651705 |
| InChI Key | UWWSCLNCHCROLL-UHFFFAOYSA-N |
| Smiles | OC(C1=CC=C(C=C1)CN2C(C3=C(N=C2SCC4=C(C#N)C=CC=C4)C=CS3)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SPL 334
References for SPL 334
References are publications that support the biological activity of the product.
Luzina et al (2015) Pharmacological in vivo inhibition of S-nitrosoglutathione reductase attenuates bleomycin-induced inflammation and fibrosis. J.Pharmacol.Exp.Ther. 355 13 PMID: 26209236
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Keywords: SPL 334, SPL 334 supplier, SPL334, S-nitrosoglutathione, reductase, inhibitors, inhibits, interstitial, lung, disease, Other, Dehydrogenases, 5809, Tocris Bioscience
Citations for SPL 334
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