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SPL 334

Cat. No. 5809 Submit a Review Datasheet / COA / SDS
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Cat.No. 5809 - SPL 334 | C22H15N3O3S2 | CAS No. 688347-51-5
Description: S-Nitrosoglutathione reductase inhibitor
Chemical Name: 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
Purity: ≥98% (HPLC)
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Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

S-Nitrosoglutathione reductase inhibitor. Prevents weight loss, and attenuates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.

Technical Data

M. Wt 433.5
Formula C22H15N3O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 688347-51-5
PubChem ID 3651705
InChI Key UWWSCLNCHCROLL-UHFFFAOYSA-N
Smiles OC(C1=CC=C(C=C1)CN2C(C3=C(N=C2SCC4=C(C#N)C=CC=C4)C=CS3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 433.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Luzina et al (2015) Pharmacological in vivo inhibition of S-nitrosoglutathione reductase attenuates bleomycin-induced inflammation and fibrosis. J.Pharmacol.Exp.Ther. 355 13 PMID: 26209236

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Citations for SPL 334

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