SPL 334

Discontinued Product

SPL 334 (Cat. No. 5809) has been withdrawn from sale for commercial reasons.
Description: S-Nitrosoglutathione reductase inhibitor
Chemical Name: 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
Purity: ≥98% (HPLC)

Biological Activity for SPL 334

SPL 334 is a S-Nitrosoglutathione reductase inhibitor. Prevents weight loss, and attenuates lung inflammation and fibrosis in a bleomycin injury model of interstitial lung disease in mice.

Technical Data for SPL 334

M. Wt 433.5
Formula C22H15N3O3S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 688347-51-5
PubChem ID 3651705
Smiles OC(C1=CC=C(C=C1)CN2C(C3=C(N=C2SCC4=C(C#N)C=CC=C4)C=CS3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SPL 334

References are publications that support the biological activity of the product.

Luzina et al (2015) Pharmacological in vivo inhibition of S-nitrosoglutathione reductase attenuates bleomycin-induced inflammation and fibrosis. J.Pharmacol.Exp.Ther. 355 13 PMID: 26209236

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Keywords: SPL 334, SPL 334 supplier, SPL334, S-nitrosoglutathione, reductase, inhibitors, inhibits, interstitial, lung, disease, Other, Dehydrogenases, 5809, Tocris Bioscience

Citations for SPL 334

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Currently there are no citations for SPL 334.

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