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Biological Activity for Spantide I
Spantide I is a selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
Technical Data for Spantide I
(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Spantide I
|Solubility||Soluble to 1 mg/ml in water|
References for Spantide I
References are publications that support the biological activity of the product.
Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793 PMID: 7682138
Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449 PMID: 6207886
Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13 PMID: 10808247
If you know of a relevant reference for Spantide I, please let us know.
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Keywords: Spantide I, Spantide I supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, [D-Arg1,D-Trp7,9,Leu11]-Substance, P, Receptor, 1784, Tocris Bioscience
Citations for Spantide I
Citations are publications that use Tocris products.
Currently there are no citations for Spantide I. Do you know of a great paper that uses Spantide I from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.