Selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo.
(Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1497.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.67 mL||3.34 mL||6.68 mL|
|5 mM||0.13 mL||0.67 mL||1.34 mL|
|10 mM||0.07 mL||0.33 mL||0.67 mL|
|50 mM||0.01 mL||0.07 mL||0.13 mL|
References are publications that support the products' biological activity.
Beaujouan et al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793 PMID: 7682138
Folkers et al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449 PMID: 6207886
Zubrzycka et al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13 PMID: 10808247
If you know of a relevant reference for Spantide I, please let us know.
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Keywords: Spantide I, supplier, Selective, NK1, antagonists, Tachykinin, Receptors, Neurokinin, SpantideI, [D-Arg1, D-Trp7, 9, Leu11]-SubstanceP, [D-Arg1,D-Trp7,9,Leu11]-Substance, P, NK1, Receptor, NK1, Receptor, Tocris Bioscience
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