SP 10

Pricing Availability   Qty
Description: Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
Purity: ≥95% (HPLC)

Biological Activity for SP 10

SP 10 is a peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro.

Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).

Technical Data for SP 10

M. Wt 1315.5
Formula C56H94N14O20S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 882157-88-2
PubChem ID 11693850
Smiles O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SP 10

Solubility Soluble to 1 mg/ml in water

References for SP 10

References are publications that support the biological activity of the product.

Ho et al (2006) Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 69 70 PMID: 16337697

If you know of a relevant reference for SP 10, please let us know.

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Keywords: SP 10, SP 10 supplier, SP10, SARS, CoV, spike, protein, peptide, potent, inhibitors, inhibits, ACE2, interaction, 7322, Tocris Bioscience

Citations for SP 10

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