SP 10

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Cat.No. 7322 - SP 10 | Ser-Thr-Ser-Gln-Lys-Ser-Ile-Val-Ala-Tyr-Thr-Met | CAS No. 882157-88-2
Description: Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Peptide originally derived from SARS-CoV Spike (S) protein; corresponds to amino acid residues 668 to 679. Highly potent inhibitor of SARS-CoV S protein and ACE2 interaction (IC50 = 1.88 nM in biochemical assay). Inhibits interaction of SARS-CoV S protein and Vero E6 cells in vitro.

Please note, this peptide displays 80% sequence identity to homologous site on SARS-CoV-2 S-protein (residues 689-697).

Technical Data

M. Wt 1315.5
Formula C56H94N14O20S
Sequence STSQKSIVAYTM
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 882157-88-2
PubChem ID 11693850
InChI Key RBLTWUZIFRZOSV-SQWMWQRLSA-N
Smiles O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Ho et al (2006) Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 69 70 PMID: 16337697


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Keywords: SP 10, SP 10 supplier, SP10, SARS, CoV, spike, protein, peptide, potent, inhibitors, inhibits, ACE2, interaction, 7322, Tocris Bioscience

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Literature in this Area

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