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A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 308.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.48 mL||32.38 mL||64.76 mL|
|2.5 mM||1.3 mL||6.48 mL||12.95 mL|
|5 mM||0.65 mL||3.24 mL||6.48 mL|
|25 mM||0.13 mL||0.65 mL||1.3 mL|
References are publications that support the biological activity of the product.
Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366
Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319
Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227
Merck Index 12 8876
If you know of a relevant reference for Sotalol hydrochloride, please let us know.
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Keywords: Sotalol hydrochloride, Sotalol hydrochloride supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Non-selective, Adrenergic, Beta, 0952, Tocris Bioscience
3 Citations for Sotalol hydrochloride
Citations are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196
Do you know of a great paper that uses Sotalol hydrochloride from Tocris? Please let us know.
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.