A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||30.88||100|
Preparing Stock Solutions
The following data is based on the product molecular weight 308.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.24 mL||16.19 mL||32.38 mL|
|5 mM||0.65 mL||3.24 mL||6.48 mL|
|10 mM||0.32 mL||1.62 mL||3.24 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366
Fiset et al (1997) Block of Iks by the diuretic agent indapamide modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319
Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227
If you know of a relevant reference for Sotalol hydrochloride, please let us know.
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Keywords: β-adrenoceptor beta-adrenoceptors b-adrenergic β-adrenergic beta-adrenergic b-adrenoceptors antagonists Receptors Non-Selective Non-selective Adrenergic Beta Receptors
2 Citations for Sotalol hydrochloride
Citations are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Do you know of a great paper that uses Sotalol hydrochloride from Tocris? If so please let us know.
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