Sotalol hydrochloride

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Cat.No. 0952 - Sotalol hydrochloride | C12H20N2O3S.HCl | CAS No. 959-24-0
Description: β antagonist
Chemical Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™.

Technical Data

M. Wt 308.82
Formula C12H20N2O3S.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 959-24-0
PubChem ID 66245
InChI Key VIDRYROWYFWGSY-UHFFFAOYSA-N
Smiles Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.44 50

Preparing Stock Solutions

The following data is based on the product molecular weight 308.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.48 mL 32.38 mL 64.76 mL
2.5 mM 1.3 mL 6.48 mL 12.95 mL
5 mM 0.65 mL 3.24 mL 6.48 mL
25 mM 0.13 mL 0.65 mL 1.3 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366

Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319

Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227

Merck Index 12 8876


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View all Non-selective Adrenergic β Receptor Antagonists

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3 Citations for Sotalol hydrochloride

Citations are publications that use Tocris products. Selected citations for Sotalol hydrochloride include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685

McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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