SNAP 398299

Discontinued Product

SNAP 398299 (Cat. No. 5426) has been withdrawn from sale for commercial reasons.
Cat.No. 5426 - SNAP 398299 | C27H24F3N3O2 | CAS No. 903878-06-8
Description: Potent and selective GAL3 antagonist
Chemical Name: 1,3-Dihydro-1-[3-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent and selective GAL3 antagonist (Ki = 5 nM). Exhibits greater than 100-fold selectively for GAL3 over GAL1, GAL2, adrenergic α1a and dopamine D5 receptors. Anxiolytic- and antidepressant-like effects in vivo.

Technical Data

M. Wt 479.49
Formula C27H24F3N3O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 903878-06-8
PubChem ID 11698643
InChI Key HXCJZIBJTFITNI-UHFFFAOYSA-N
Smiles O=C3/C(C2=CC=CC=C2N3C4=CC(OCCN5CCCC5)=CC=C4)=N/C1=CC=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Swanson et al (2005) Anxiolytic- and antidepressant-like profiles of the galanin-3 (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc.Natl.Acad.Sci.U.S.A 102 17489 PMID: 16287967

Konkel et al (2006) Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorg.Med.Chem.Lett. 16 3950 PMID: 16730981

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