Potent and selective GAL3 antagonist (Ki = 5 nM). Exhibits greater than 100-fold selectively for GAL3 over GAL1, GAL2, adrenergic α1a and dopamine D5 receptors. Anxiolytic- and antidepressant-like effects in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 479.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.09 mL||10.43 mL||20.86 mL|
|5 mM||0.42 mL||2.09 mL||4.17 mL|
|10 mM||0.21 mL||1.04 mL||2.09 mL|
|50 mM||0.04 mL||0.21 mL||0.42 mL|
References are publications that support the products' biological activity.
Swanson et al (2005) Anxiolytic- and antidepressant-like profiles of the galanin-3 (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc.Natl.Acad.Sci.U.S.A 102 17489 PMID: 16287967
Konkel et al (2006) Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorg.Med.Chem.Lett. 16 3950 PMID: 16730981
If you know of a relevant reference for SNAP 398299, please let us know.
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Keywords: SNAP 398299, supplier, SNAP398299, high, affinity, selective, gal3, antagonists, antagonism, galanin, Galanin, Receptors, Galanin, Receptors, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.