SNAP 398299

Discontinued Product

SNAP 398299 (Cat. No. 5426) has been withdrawn from sale for commercial reasons.
Description: Potent and selective GAL3 antagonist
Chemical Name: 1,3-Dihydro-1-[3-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-[[3-(trifluoromethyl)phenyl]imino]-2H-indol-2-one
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity for SNAP 398299

Potent and selective GAL3 antagonist (Ki = 5 nM). Exhibits greater than 100-fold selectively for GAL3 over GAL1, GAL2, adrenergic α1a and dopamine D5 receptors. Anxiolytic- and antidepressant-like effects in vivo.

Technical Data for SNAP 398299

M. Wt 479.49
Formula C27H24F3N3O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 903878-06-8
PubChem ID 11698643
Smiles O=C3/C(C2=CC=CC=C2N3C4=CC(OCCN5CCCC5)=CC=C4)=N/C1=CC=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SNAP 398299

References are publications that support the biological activity of the product.

Swanson et al (2005) Anxiolytic- and antidepressant-like profiles of the galanin-3 (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc.Natl.Acad.Sci.U.S.A 102 17489 PMID: 16287967

Konkel et al (2006) Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility. Bioorg.Med.Chem.Lett. 16 3950 PMID: 16730981

View Related Products by Target

View Related Products by Product Action

View all Galanin Receptor Antagonists

Keywords: SNAP 398299, SNAP 398299 supplier, SNAP398299, high, affinity, selective, gal3, antagonists, antagonism, galanin, Galanin, Receptors, 5426, Tocris Bioscience

Citations for SNAP 398299

Citations are publications that use Tocris products.

Currently there are no citations for SNAP 398299.

Reviews for SNAP 398299

There are currently no reviews for this product. Be the first to review SNAP 398299 and earn rewards!

Have you used SNAP 398299?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.