SMIFH2

Discontinued Product

4401 has been discontinued.

View all Actin products.
Description: FH2 domain inhibitor; prevents actin nucleation
Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Purity: ≥99% (HPLC)
Datasheet
Citations (12)
Reviews

Biological Activity for SMIFH2

SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.

Technical Data for SMIFH2

M. Wt 377.21
Formula C15H9BrN2O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 340316-62-3
PubChem ID 2258538
InChI Key MVFJHEQDISFYIS-XYOKQWHBSA-N
Smiles O=C(/C(C(N2)=O)=C/C1=CC=CO1)N(C3=CC=CC(Br)=C3)C2=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SMIFH2

References are publications that support the biological activity of the product.

Rizvi et al (2009) Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem.Biol. 16 1158 PMID: 19942139

Poincloux et al (2011) Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc.Natl.Acad.Sci.USA 108 1943 PMID: 21245302

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Keywords: SMIFH2, SMIFH2 supplier, SMIFH2, formins, homology, fh2, domains, inhibitors, inhibits, actin, nucleation, Actin, 4401, Tocris Bioscience

12 Citations for SMIFH2

Citations are publications that use Tocris products. Selected citations for SMIFH2 include:

LeCorgne et al (2018) Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish. Front Pharmacol 9 340 PMID: 29692731

Sepúlveda-Ramírez et al (2018) Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol 437 140 PMID: 29555242

Daniel L et al (2022) Nuclear F-actin and Lamin A antagonistically modulate nuclear shape. J Cell Sci 135 PMID: 35665815

Matthieu et al (2019) Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration. Dev Cell 49 171-188.e5 PMID: 30982662


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