SMANT hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4662 - SMANT hydrochloride | C16H23BrN2O.HCl | CAS No. 1177600-74-6
Description: Inhibits Smoothened (Smo) accumulation
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M. Wt 375.73
Formula C16H23BrN2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1177600-74-6
PubChem ID 2900213
Smiles BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.57 100
water 7.51 20

Preparing Stock Solutions

The following data is based on the product molecular weight 375.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.31 mL 26.61 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040 PMID: 22554036

If you know of a relevant reference for SMANT hydrochloride, please let us know.

Keywords: SMANT hydrochloride, supplier, Smoothened, Smo, hedgehog, Hh, signaling, signalling, inhibitors, inhibits, SMANT, Smoothened, Receptors, Hedgehog, Signaling, Smoothened, Receptors, Tocris Bioscience

Citations for SMANT hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for SMANT hydrochloride. Do you know of a great paper that uses SMANT hydrochloride from Tocris? If so please let us know.

Reviews for SMANT hydrochloride

There are currently no reviews for this product. Be the first to review SMANT hydrochloride and earn rewards!

Have you used SMANT hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling