SMANT hydrochloride

Discontinued Product

SMANT hydrochloride (Cat. No. 4662) has been withdrawn from sale for commercial reasons.
Description: Inhibits Smoothened (Smo) accumulation
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for SMANT hydrochloride

SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data for SMANT hydrochloride

M. Wt 375.73
Formula C16H23BrN2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1177600-74-6
PubChem ID 2900213
Smiles BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for SMANT hydrochloride

References for SMANT hydrochloride

References are publications that support the biological activity of the product.

Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040 PMID: 22554036

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Citations for SMANT hydrochloride

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