SMANT hydrochloride

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Cat.No. 4662 - SMANT hydrochloride | C16H23BrN2O.HCl | CAS No. 1177600-74-6
Description: Inhibits Smoothened (Smo) accumulation
Chemical Name: N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride
Purity: ≥99% (HPLC)
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Biological Activity

Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Technical Data

M. Wt 375.73
Formula C16H23BrN2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1177600-74-6
PubChem ID 2900213
InChI Key XQESCHFXROUCOQ-UHFFFAOYSA-N
Smiles BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.51 20
DMSO 37.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 375.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.31 mL 26.61 mL
5 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Wang et al (2012) Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 7 1040 PMID: 22554036


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