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Submit ReviewSLV 320 is a potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
M. Wt | 308.38 |
Formula | C18H20N4O |
Storage | Store at -20°C |
Purity | ≥99% (HPLC) |
CAS Number | 251945-92-3 |
PubChem ID | 9953065 |
InChI Key | RBZNJGHIKXAKQE-UHFFFAOYSA-N |
Smiles | O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436
Keywords: SLV 320, SLV 320 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Adenosine, 3344, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SLV 320 include:
Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806
Badders (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbarmuscular atrophy. Nat Med 24 424 PMID: 29505030
Average Rating: 5 (Based on 1 Review.)
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To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222