SLV 320
Biological Activity
Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
Technical Data
| M. Wt | 308.38 |
| Formula | C18H20N4O |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 251945-92-3 |
| PubChem ID | 9953065 |
| InChI Key | RBZNJGHIKXAKQE-UHFFFAOYSA-N |
| Smiles | O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.84 | 100 | |
| ethanol | 15.42 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.21 mL | 32.43 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.49 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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References
References are publications that support the products' biological activity.
Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436
If you know of a relevant reference for SLV 320, please let us know.
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Keywords: Potent selective A1 antagonists Receptors adenosines SLV320 Adenosine A1 Receptors
Citations for SLV 320
Citations are publications that use Tocris products.
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