You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.24 mL||16.21 mL||32.43 mL|
|5 mM||0.65 mL||3.24 mL||6.49 mL|
|10 mM||0.32 mL||1.62 mL||3.24 mL|
|50 mM||0.06 mL||0.32 mL||0.65 mL|
References are publications that support the biological activity of the product.
Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436
If you know of a relevant reference for SLV 320, please let us know.
View Related Products by Product Action
Keywords: SLV 320, SLV 320 supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Adenosine, 3344, Tocris Bioscience
2 Citations for SLV 320
Citations are publications that use Tocris products. Selected citations for SLV 320 include:
Badders (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbarmuscular atrophy. Nat Med 24 424 PMID: 29505030
Cheng et al (2017) Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity. Structure 25 1275 PMID: 28712806
Do you know of a great paper that uses SLV 320 from Tocris? Please let us know.
Reviews for SLV 320
Average Rating: 5 (Based on 1 Review.)
Have you used SLV 320?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.