SLV 320

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Cat.No. 3344 - SLV 320 | C18H20N4O | CAS No. 251945-92-3
Description: Potent and selective A1 antagonist
Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

Technical Data

M. Wt 308.38
Formula C18H20N4O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 251945-92-3
PubChem ID 9953065
InChI Key RBZNJGHIKXAKQE-UHFFFAOYSA-N
Smiles O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100
ethanol 15.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436


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Literature in this Area

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Pathways for SLV 320

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