SLV 320

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Cat.No. 3344 - SLV 320 | C18H20N4O | CAS No. 251945-92-3
Description: Potent and selective A1 antagonist
Chemical Name: trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Potent and selective adenosine A1 receptor antagonist (Ki values are 1, 200, 398 and 3981 nM at human A1, A3, A2A and A2B receptors respectively). Suppresses cardiac fibrosis and attenuates albuminuria, without effect on blood pressure in animal models of chronic renal failure. Orally active.

Technical Data

M. Wt 308.38
Formula C18H20N4O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 251945-92-3
PubChem ID 9953065
InChI Key RBZNJGHIKXAKQE-UHFFFAOYSA-N
Smiles O[C@@H](CC4)CC[C@H]4NC1=C2C(NC=C2)=NC(C3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100
ethanol 15.42 50

Preparing Stock Solutions

The following data is based on the product molecular weight 308.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kalk et al (2007) The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without effecting blood pressure. Br.J.Pharmacol. 151 1025 PMID: 17558436


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Keywords: SLV 320, supplier, Potent, selective, A1, antagonists, Receptors, adenosines, SLV320, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience

1 Citation for SLV 320

Citations are publications that use Tocris products. Selected citations for SLV 320 include:

Badders (2018) Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbarmuscular atrophy. Nat Med 24 424 PMID: 29505030


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Reviews for SLV 320

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SLV320 to inhibit adenosine A1 receptor in piglet afferent arteriole
By Hitesh Soni on 01/04/2018
Assay Type: In Vitro
Species: Other
Cell Line/Tissue: Renal Afferent Arteriole

To inhibit adenosine A1 receptor in isolated pig afferent arteriole from kidney. We have performed calcium imaging study using this compound. We have also used pyr3 from Tocris and published results in AJP-renal journal recently. American Journal of Physiology-Renal Physiology 313 (6), F1216-F1222

PMID: 28855189
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Literature in this Area

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