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Description: Potent pan-ERR agonist
Chemical Name: (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for SLU-PP-332

SLU-PP-332 is a potent and selective pan estrogen related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRα, ERRβ and ERRγ respectively). In a mouse model of metabolic syndrome SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. Also increases mitochondrial respiration in vitro.

Technical Data for SLU-PP-332

M. Wt 290.32
Formula C18H14N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 303760-60-3
PubChem ID 5404083
Smiles O=C(C1=CC=C(C=C1)O)N/N=C/C2=CC3=C(C=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SLU-PP-332

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.03 100

Preparing Stock Solutions for SLU-PP-332

The following data is based on the product molecular weight 290.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.22 mL 34.44 mL
5 mM 0.69 mL 3.44 mL 6.89 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References for SLU-PP-332

References are publications that support the biological activity of the product.

Billon et al (2023) Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem.Biol. 18 756 PMID: 36988910

Billon et al (2024) A synthetic ERR agonist alleviates metabolic syndrome. J.Pharmacol.Exp.Ther. 388 232 PMID: 37739806

If you know of a relevant reference for SLU-PP-332, please let us know.

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Keywords: SLU-PP-332, SLU-PP-332 supplier, SLUPP332, ERR, estrogen, related, receptor, receptors, agonist, agonists, ERRalpha, beta, gamma, mitochondrial, respiration, metabolic, syndrome, obesity, insulin, sensitivity, Estrogen, and, Related, Receptors, 8112, Tocris Bioscience

Citations for SLU-PP-332

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Pathways for SLU-PP-332

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.