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Description: PAR2-activating peptide
Purity: ≥95% (HPLC)
Citations (7)
Reviews (1)

Biological Activity for SLIGRL-NH2

SLIGRL-NH2 is an agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.

Control Peptide also available.

Technical Data for SLIGRL-NH2

M. Wt 656.82
Formula C29H56N10O7
Sequence SLIGRL

(Modifications: Leu-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 171436-38-7
PubChem ID 9831050
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SLIGRL-NH2

Solubility Soluble to 1 mg/ml in water

Product Datasheets for SLIGRL-NH2

Certificate of Analysis / Product Datasheet
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References for SLIGRL-NH2

References are publications that support the biological activity of the product.

Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203 PMID: 8564891

Kawabata et al (2001) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br.J.Pharmacol. 133 1213 PMID: 11498505

Nystedt et al (1994) Molecular cloning of a potential proteinase activated receptor. Proc.Natl.Acad.Sci.U.S.A. 91 9208 PMID: 7937743

If you know of a relevant reference for SLIGRL-NH2, please let us know.

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Keywords: SLIGRL-NH2, SLIGRL-NH2 supplier, PAR2-activating, peptide, Receptors, Protease-Activated, proteinase-activated, 1468, Tocris Bioscience

7 Citations for SLIGRL-NH2

Citations are publications that use Tocris products. Selected citations for SLIGRL-NH2 include:

Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131

Vidwan et al (2010) Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30 2587 PMID: 20930172

Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. PLoS One 30 582 PMID: 21139565

Pandey et al (2017) A central role for R7bp in the regulation of itch sensation. Pain 158 931 PMID: 28134655

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278

Antoniak et al (2013) Protease activated receptor-2 contributes to heart failure. EMBO J 8 e81733 PMID: 24312345

Sutherland et al (2019) Virus envelope tissue factor promotes infection in mice. J Thromb Haemost 17 482 PMID: 30659719

Do you know of a great paper that uses SLIGRL-NH2 from Tocris? Please let us know.

Reviews for SLIGRL-NH2

Average Rating: 5 (Based on 1 Review.)

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Good and easy product to use for regular in-vitro stimulations.
By Anonymous on 11/20/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Smooth Muscle Cells

Inv-vitro stimulation of PAR2 receptor in Smooth muscle cells