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Agonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo.
Control Peptide also available.
(Modifications: Leu-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203 PMID: 8564891
Kawabata et al (2001) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br.J.Pharmacol. 133 1213 PMID: 11498505
Nystedt et al (1994) Molecular cloning of a potential proteinase activated receptor. Proc.Natl.Acad.Sci.U.S.A. 91 9208 PMID: 7937743
If you know of a relevant reference for SLIGRL-NH2, please let us know.
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Keywords: SLIGRL-NH2, SLIGRL-NH2 supplier, PAR2-activating, peptide, Receptors, Protease-Activated, proteinase-activated, 1468, Tocris Bioscience
6 Citations for SLIGRL-NH2
Citations are publications that use Tocris products. Selected citations for SLIGRL-NH2 include:
Pandey et al (2017) A central role for R7bp in the regulation of itch sensation. Pain 158 931 PMID: 28134655
Antoniak et al (2013) Protease activated receptor-2 contributes to heart failure. EMBO J 8 e81733 PMID: 24312345
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. PLoS One 30 582 PMID: 21139565
Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61 PMID: 20875131
Vidwan et al (2010) Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30 2587 PMID: 20930172
Do you know of a great paper that uses SLIGRL-NH2 from Tocris? Please let us know.
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