Protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2. Control peptide VKGILS-NH2 also available (Cat. No. 3392).
(Modifications: Val-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 614.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.63 mL||8.13 mL||16.27 mL|
|5 mM||0.33 mL||1.63 mL||3.25 mL|
|10 mM||0.16 mL||0.81 mL||1.63 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752
Hollenberg and Compton (2002) International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 54 203 PMID: 12037136
Kanke et al (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br.J.Pharmacol. 145 255 PMID: 15765104
If you know of a relevant reference for SLIGKV-NH2, please let us know.
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Keywords: PAR2 receptor agonists Receptors Protease-Activated proteinase-activated Protease-Activated Receptors
1 Citation for SLIGKV-NH2
Citations are publications that use Tocris products. Selected citations for SLIGKV-NH2 include:
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672
Do you know of a great paper that uses SLIGKV-NH2 from Tocris? If so please let us know.