SLIGKV-NH2

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Cat.No. 3010 - SLIGKV-NH2 | Ser-Leu-Ile-Gly-Lys-Val-NH2 | CAS No. 190383-13-2
Description: PAR2 receptor agonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2. Control peptide VKGILS-NH2 also available (Cat. No. 3392).

Technical Data

M. Wt 614.78
Formula C28H54N8O7
Sequence SLIGKV

(Modifications: Val-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 190383-13-2
PubChem ID 10483914
InChI Key HOWDUIVVWDUEED-WAUHAFJUSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 614.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752

Hollenberg and Compton (2002) International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 54 203 PMID: 12037136

Kanke et al (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br.J.Pharmacol. 145 255 PMID: 15765104


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Keywords: SLIGKV-NH2, supplier, PAR2, receptor, agonists, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience

1 Citation for SLIGKV-NH2

Citations are publications that use Tocris products. Selected citations for SLIGKV-NH2 include:

Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672


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