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SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM and IC50 = 10.4 μM). Corresponds to the tethered ligand exposed by trypsin cleavage of PAR-2.
Control Peptide also available.
(Modifications: Val-6 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Bohm et al (1996) Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem.J. 314 1009 PMID: 8615752
Hollenberg and Compton (2002) International union of pharmacology XXVIII. Proteinase-activated receptors. Pharmacol.Rev. 54 203 PMID: 12037136
Kanke et al (2005) Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2. Br.J.Pharmacol. 145 255 PMID: 15765104
If you know of a relevant reference for SLIGKV-NH2, please let us know.
Keywords: SLIGKV-NH2, SLIGKV-NH2 supplier, PAR2, receptor, agonists, Receptors, Protease-Activated, proteinase-activated, 3010, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SLIGKV-NH2 include:
Namkung et al (2016) Monitoring G protein-coupled receptor and [beta]-arrestin trafficking in live cells using enhanced bystander BRET Nature Communications 7 12178 PMID: 27397672
Do you know of a great paper that uses SLIGKV-NH2 from Tocris? Please let us know.
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