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Submit ReviewSKI 178
Description: Non-lipid sphingosine kinase 1 (SphK1) inhibitor
Chemical Name: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
Purity: ≥98% (HPLC)
Biological Activity for SKI 178
Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.
Technical Data for SKI 178
| M. Wt | 394.42 |
| Formula | C21H22N4O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1259484-97-3 |
| PubChem ID | 5342941 |
| InChI Key | GMFUWEBOUKIKRP-LPYMAVHISA-N |
| Smiles | O=C(N/N=C(C)/C1=CC=C(OC)C(OC)=C1)C2=CC(C3=CC=C(OC)C=C3)=NN2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SKI 178
References for SKI 178
References are publications that support the biological activity of the product.
Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902
Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755
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Keywords: SKI 178, SKI 178 supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Kinase, 5452, Tocris Bioscience
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