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Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902
Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755
Keywords: SKI 178, SKI 178 supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Kinase, 5452, Tocris Bioscience
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