Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 394.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.54 mL||12.68 mL||25.35 mL|
|5 mM||0.51 mL||2.54 mL||5.07 mL|
|10 mM||0.25 mL||1.27 mL||2.54 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902
Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755
If you know of a relevant reference for SKI 178, please let us know.
View Related Products by Product Action
Keywords: SKI 178, supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Sphingosine, Kinase, Sphingosine, Kinase, Tocris Bioscience
Citations for SKI 178
Citations are publications that use Tocris products.
Currently there are no citations for SKI 178. Do you know of a great paper that uses SKI 178 from Tocris? If so please let us know.