SKI 178

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Cat.No. 5452 - SKI 178 | C21H22N4O4 | CAS No. 1259484-97-3
Description: Non-lipid sphingosine kinase 1 (SphK1) inhibitor
Chemical Name: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.

Technical Data

M. Wt 394.42
Formula C21H22N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1259484-97-3
PubChem ID 5342941
InChI Key GMFUWEBOUKIKRP-LPYMAVHISA-N
Smiles O=C(N/N=C(C)/C1=CC=C(OC)C(OC)=C1)C2=CC(C3=CC=C(OC)C=C3)=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902

Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755


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Keywords: SKI 178, supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Sphingosine, Kinase, Sphingosine, Kinase, Tocris Bioscience

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