SKI 178

Discontinued Product

SKI 178 (Cat. No. 5452) has been withdrawn from sale for commercial reasons.
Description: Non-lipid sphingosine kinase 1 (SphK1) inhibitor
Chemical Name: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
Purity: ≥98% (HPLC)

Biological Activity for SKI 178

Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.

Technical Data for SKI 178

M. Wt 394.42
Formula C21H22N4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1259484-97-3
PubChem ID 5342941
Smiles O=C(N/N=C(C)/C1=CC=C(OC)C(OC)=C1)C2=CC(C3=CC=C(OC)C=C3)=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for SKI 178

References are publications that support the biological activity of the product.

Dick et al (2015) The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines. J.Pharmacol.Exp.Ther. 352 494 PMID: 25563902

Hengst et al (2010) Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg.Med.Chem.Lett. 20 7498 PMID: 21050755

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Keywords: SKI 178, SKI 178 supplier, SKI178, Inhibitors, Inhibits, Sphingosine, kinase, 1, SphK1, Kinase, 5452, Tocris Bioscience

Citations for SKI 178

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Currently there are no citations for SKI 178.

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